Moss H B, Guthrie S, Linnoila M
Arch Gen Psychiatry. 1986 Dec;43(12):1137-42. doi: 10.1001/archpsyc.1986.01800120023005.
Alcoholism is three times more prevalent in men than in women. We studied responses of thyrotropin to protirelin (thyrotropin releasing hormone) in nine sons and eight daughters of patients with familial alcoholism and in eight control boys and seven control girls. Basal and protirelin stimulated triiodothyronine, prolactin, and growth hormone concentrations were also measured. The controls were matched for age, sex, and past alcohol exposure with the index children. The sons of familial alcoholics had significantly higher basal thyrotropin levels, peak thyrotropin levels, and thyrotropin areas under the curve than did the control boys. The daughters of patients with familial alcoholism showed no differences from the control girls. Analyses of triiodothyronine, prolactin, and growth hormone concentrations revealed no differences between the index children and controls. We believe that this is the first report of a male-limited neuroendocrine difference between children of alcoholics and control children. Further studies are needed to elucidate the clinical significance of our preliminary findings.
酒精中毒在男性中的患病率是女性的三倍。我们研究了家族性酒精中毒患者的九个儿子和八个女儿以及八个对照男孩和七个对照女孩对促甲状腺素释放激素（TRH）刺激的促甲状腺素反应。同时还测量了基础及TRH刺激后的三碘甲状腺原氨酸、催乳素和生长激素浓度。对照者在年龄、性别和既往酒精暴露情况方面与受试儿童相匹配。家族性酒精中毒患者的儿子相比对照男孩，其基础促甲状腺素水平、促甲状腺素峰值水平以及曲线下面积显著更高。家族性酒精中毒患者的女儿与对照女孩之间未显示出差异。对三碘甲状腺原氨酸、催乳素和生长激素浓度的分析表明，受试儿童与对照者之间没有差异。我们认为这是关于酒精中毒患者子女与对照儿童之间存在男性特有的神经内分泌差异的首篇报道。需要进一步研究以阐明我们初步研究结果的临床意义。
