Khazdair Mohammad Reza, Anaeigoudari Akbar, Hashemzehi Milad, Mohebbati Reza
Neurogenic Inflammation Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
J Tradit Complement Med. 2018 Apr 30;9(2):98-105. doi: 10.1016/j.jtcme.2018.01.002. eCollection 2019 Apr.
In recent years, growing attention has been given to traditional medicine. In traditional medicine a large number of plants have been used to cure neurodegenerative diseases such as Alzheimers disease (AD) and other memory related disorders. (), () and () were used traditionally for dietary, food additive, spice and various medicinal purposes. The Major components of these herbs are carotenoids, monoterpenes and poly phenol compounds which enhanced the neural functions. These medicinal plants increased anti-oxidant, decreased oxidant levels and inhibited acetylcholinesterase activity in the neural system. Furthermore, neuroprotective of plants occur via reduced pro-inflammatory cytokines such as IL-6, IL-1β, TNF-α and total nitrite generation. Therefore, the effects of the above mentioned medicinal and their active constituents improved neurodegenerative diseases which indicate their therapeutic potential in disorders associated with neuro-inflammation and neurotransmitter deficiency such as AD and depression.
近年来，传统医学越来越受到关注。在传统医学中，大量植物被用于治疗神经退行性疾病，如阿尔茨海默病（AD）和其他与记忆相关的疾病。（）、（）和（）传统上用于饮食、食品添加剂、香料和各种药用目的。这些草药的主要成分是类胡萝卜素、单萜和多酚化合物，它们增强了神经功能。这些药用植物增加了抗氧化剂，降低了氧化剂水平，并抑制了神经系统中的乙酰胆碱酯酶活性。此外，植物的神经保护作用是通过减少促炎细胞因子如IL-6、IL-1β、TNF-α和总亚硝酸盐的产生来实现的。因此，上述药物及其活性成分的作用改善了神经退行性疾病，这表明它们在与神经炎症和神经递质缺乏相关的疾病如AD和抑郁症中具有治疗潜力。
