Institute for Clinical Neurosciences and German Center for Vertigo and Balance Disorders, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Department of Neurology, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
J Neurol. 2019 Sep;266(Suppl 1):3-8. doi: 10.1007/s00415-019-09300-5. Epub 2019 Apr 9.
To determine if the risk of traffic accidents increases after disease onset in patients with acute vestibular disorders. That could provide a valid rationale for guidelines on driving restrictions.
5,260,054 patient data (> 18 years of age) from a statutory health insurer were used to identify traffic injuries in incident cases of Menière's disease (MD) and vestibular neuritis (VN) in 2010-2013. Incident diagnoses were defined as the absence of such diagnoses in the preceding 5 years. Comparators were insured individuals with no such diagnoses throughout 2005-2017. The surrogate for traffic injuries were whiplash injuries coded in ICD-10 as diagnosis of sprain of ligaments of the cervical spine without structural changes.
We identified 4509 incident patients with Menière's disease and 25,448 with vestibular neuritis and 5,102,655 controls with no such diagnoses throughout the observation period. The incidence of traffic injuries was increased for both vestibular disorders prior to the time point of diagnosis-MD 0.72 [0.47; 0.97] and VN 0.66 [0.56; 0.76] compared to controls (0.46 [0.46; 0.47]). The temporal course of incidence in whiplash injuries showed no increase and was 0.64 [0.41; 0.88] for MD at diagnosis and 0.73 [0.48; 0.98] after diagnosis, for VN it was 0.81 [0.70; 0.92] at diagnosis and 0.65 [0.55; 0.74] after diagnosis.
Although these data were not originally collected to address the research question, they provide a valid body of evidence. There is no rationale for driving restrictions, which substantially interfere with the individuals' quality of life, in patients with incident MD and VN.
确定急性前庭障碍患者发病后发生交通事故的风险是否增加。这可以为驾驶限制指南提供合理依据。
利用一家法定健康保险公司的 526 万 054 名(年龄>18 岁)患者数据,于 2010-2013 年确定美尼尔氏病(MD)和前庭神经炎(VN)的首发病例中的交通伤害。首发诊断定义为在之前 5 年内没有此类诊断。对照组为在 2005-2017 年期间没有此类诊断的参保人员。交通伤害的替代指标是 ICD-10 中编码的挥鞭样损伤,诊断为颈椎韧带扭伤而无结构改变。
我们在观察期间共确定了 4509 例首发 MD 患者、25448 例 VN 患者和 5102655 例无此类诊断的对照者。在诊断时间点之前,两种前庭障碍的交通伤害发生率均升高-MD 为 0.72 [0.47; 0.97],VN 为 0.66 [0.56; 0.76],与对照组(0.46 [0.46; 0.47])相比。挥鞭样损伤的发病时间进程显示无增加,MD 诊断时为 0.64 [0.41; 0.88],诊断后为 0.73 [0.48; 0.98],VN 诊断时为 0.81 [0.70; 0.92],诊断后为 0.65 [0.55; 0.74]。
尽管这些数据最初并非为解决研究问题而收集,但它们提供了合理的证据。因此,对于新发 MD 和 VN 患者,没有理由限制驾驶,因为这会严重干扰患者的生活质量。