Dalton R, Chan L, Batten E, Eridani S
Br J Haematol. 1986 Oct;64(2):397-406. doi: 10.1111/j.1365-2141.1986.tb04133.x.
A 57-year-old female patient, admitted for an acute abdominal syndrome, was found to have an extensive proliferation of mast cells both in the peripheral blood and the bone marrow. Cytochemical studies confirmed the mast cell characteristics of the pathological cell population, while the immunophenotype strongly suggested a bone marrow origin of this malignancy. The course of the disease was not affected by antiproliferative treatment and the patient, after progressive general deterioration, died of intractable haemorrhage. On both clinical and haematological criteria it seems possible to distinguish this rare case of primary mast leukaemia from the more common form of tissue mastocytosis with secondary leukaemia.
一名57岁女性患者因急性腹部综合征入院，外周血和骨髓中均发现肥大细胞广泛增殖。细胞化学研究证实了病理细胞群的肥大细胞特征，而免疫表型强烈提示该恶性肿瘤起源于骨髓。疾病进程不受抗增殖治疗影响，患者在全身状况逐渐恶化后死于顽固性出血。根据临床和血液学标准，似乎有可能将这种罕见的原发性肥大细胞白血病病例与更常见的伴有继发性白血病的组织肥大细胞增多症区分开来。
