Pompidou A, Corral M, Michel P, Kruh J, Curran T
C R Acad Sci III. 1986;303(11):445-7.
After stimulation of human lymphocytes by 12-0 tetradecanoyl phorbol acetate (TPA) and by the calcium ionophore A23187 an early transient expression of proto-oncogene fos followed by an expression of c-myc is observed, as has been described in rodent fibroblast stimulated by growth factors. This observation suggests a direct role of protein Kinase C and of calcium flux an the induction of cellular oncogenes fos and myc that may be associated with the early steps of activation and proliferation of lymphocytes.
用12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）和钙离子载体A23187刺激人淋巴细胞后，观察到原癌基因fos的早期瞬时表达，随后是c - myc的表达，这与生长因子刺激的啮齿动物成纤维细胞中所描述的情况相同。这一观察结果表明蛋白激酶C和钙通量在诱导细胞癌基因fos和myc中具有直接作用，这可能与淋巴细胞激活和增殖的早期步骤相关。
