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羟丙基β-环糊精低聚物对荧蒽的增溶作用及其在生物修复中的应用

Enhanced Solubilization of Fluoranthene by Hydroxypropyl β-Cyclodextrin Oligomer for Bioremediation.

作者信息

Park Kyeong Hui, Choi Jae Min, Cho Eunae, Jung Seunho

机构信息

Department of Systems Biotechnology, Microbial Carbohydrate Resource Bank (MCRB), Center for Biotechnology Research in UBITA (CBRU), Konkuk University, Seoul 05029, Korea.

Center for Biotechnology Research in UBITA (CBRU), Institute for Ubiquitous Information Technology and Applications (UBITA), Konkuk University, Seoul 05029, Korea.

出版信息

Polymers (Basel). 2018 Jan 24;10(2):111. doi: 10.3390/polym10020111.

DOI:10.3390/polym10020111
PMID:30966147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6415056/
Abstract

Fluoranthene (FT) is a polycyclic aromatic hydrocarbon (PAH), consisting of naphthalene and benzene rings connected by a five-member ring. It is widespread in the environment. The hydrophobicity of FT limits its availability for biological uptake and degradation. In this study, hydroxypropyl β-cyclodextrin oligomers (HP-β-CD-ol) were synthesized with epichlorohydrin (EP), while the solubility enhancement of FT by HP-β-CD-ol was investigated in water. The synthesized HP-β-CD-ol was characterized by MALDI-TOF mass spectrometry (MS), ¹H NMR, and C NMR spectroscopy. The solubility of FT increased 178-fold due to the complex formation with HP-β-CD oligomers. The inclusion complexes of FT/HP-β-CD-ol were analyzed using Fourier-Transform Infrared (FT-IR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscope (SEM), and Nuclear Overhauser Effect Spectroscopy Nuclear magnetic resonance (NOESY NMR) spectroscopy. On the basis of these results, HP-β-CD-ol is recommended as a potential solubilizer for the development of PAH removal systems.

摘要

荧蒽（FT）是一种多环芳烃（PAH），由通过五元环连接的萘环和苯环组成。它在环境中广泛存在。FT的疏水性限制了其被生物吸收和降解的可能性。在本研究中，用环氧氯丙烷（EP）合成了羟丙基β-环糊精低聚物（HP-β-CD-ol），并研究了HP-β-CD-ol在水中对FT溶解度的增强作用。通过基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）、¹H NMR和¹³C NMR光谱对合成的HP-β-CD-ol进行了表征。由于与HP-β-CD低聚物形成络合物，FT的溶解度增加了178倍。使用傅里叶变换红外光谱（FT-IR）、差示扫描量热法（DSC）、扫描电子显微镜（SEM）和核Overhauser效应光谱核磁共振（NOESY NMR）光谱对FT/HP-β-CD-ol的包合物进行了分析。基于这些结果，推荐将HP-β-CD-ol作为开发PAH去除系统的潜在增溶剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/ffabc66cc2c4/polymers-10-00111-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/89bbf0edbb95/polymers-10-00111-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/7fd217c2bd2f/polymers-10-00111-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/7403ffdb16e0/polymers-10-00111-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/478d4258151d/polymers-10-00111-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/5525eac29556/polymers-10-00111-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/efeeaf2715ad/polymers-10-00111-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/c182667e4cea/polymers-10-00111-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/e080a4d5a5a6/polymers-10-00111-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/ffabc66cc2c4/polymers-10-00111-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/89bbf0edbb95/polymers-10-00111-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/7fd217c2bd2f/polymers-10-00111-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/7403ffdb16e0/polymers-10-00111-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/478d4258151d/polymers-10-00111-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/5525eac29556/polymers-10-00111-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/efeeaf2715ad/polymers-10-00111-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/c182667e4cea/polymers-10-00111-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/e080a4d5a5a6/polymers-10-00111-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/784a/6415056/ffabc66cc2c4/polymers-10-00111-g009.jpg

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本文引用的文献

1
Biodegradation of fluoranthene by a newly isolated strain of Bacillus stratosphericus from Mediterranean seawater of the Sfax fishing harbour, Tunisia.突尼斯斯法克斯渔港地中海海水中新分离的平流层芽孢杆菌菌株对荧蒽的生物降解作用。
Environ Sci Pollut Res Int. 2016 Aug;23(15):15088-100. doi: 10.1007/s11356-016-6648-7. Epub 2016 Apr 16.
2
Synthesis and Characterization of the Inclusion Complex of β-cyclodextrin and Azomethine.β-环糊精与亚甲胺包合物的合成与表征。
Int J Mol Sci. 2013 Feb 7;14(2):3671-82. doi: 10.3390/ijms14023671.
3
An investigation into the supramolecular structure, solubility, stability and antioxidant activity of rutin/cyclodextrin inclusion complex.
芦丁/环糊精包合物的超分子结构、溶解度、稳定性和抗氧化活性研究。
Food Chem. 2013 Jan 1;136(1):186-92. doi: 10.1016/j.foodchem.2012.07.104. Epub 2012 Aug 3.
4
Inclusion complex of novel curcumin analogue CDF and β-cyclodextrin (1:2) and its enhanced in vivo anticancer activity against pancreatic cancer.新型姜黄素类似物 CDF 与β-环糊精（1:2）的包合物及其对胰腺癌体内抗癌活性的增强作用。
Pharm Res. 2012 Jul;29(7):1775-86. doi: 10.1007/s11095-012-0700-1. Epub 2012 Feb 10.
5
Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures.一些非杂环多环芳烃及一些相关暴露因素。
IARC Monogr Eval Carcinog Risks Hum. 2010;92:1-853.
6
Host-guest interaction of 1,4-dihydroxy-9,10-anthraquinone (quinizarin) with cyclodextrins.1,4 - 二羟基 - 9,10 - 蒽醌（醌茜）与环糊精的主客体相互作用
Photochem Photobiol Sci. 2009 Jan;8(1):82-90. doi: 10.1039/b815294b. Epub 2008 Oct 29.
7
Enrichment, isolation, and phylogenetic identification of polycyclic aromatic hydrocarbon-degrading bacteria from Elizabeth River sediments.从伊丽莎白河沉积物中富集、分离和系统发育鉴定多环芳烃降解细菌。
Appl Environ Microbiol. 2008 Feb;74(4):1176-82. doi: 10.1128/AEM.01518-07. Epub 2007 Dec 21.
8
Development and pharmacological evaluation of ropivacaine-2-hydroxypropyl-beta-cyclodextrin inclusion complex.罗哌卡因-2-羟丙基-β-环糊精包合物的研制与药理评价
Eur J Pharm Sci. 2008 Jan;33(1):60-71. doi: 10.1016/j.ejps.2007.09.010. Epub 2007 Oct 7.
9
Influence of nonionic surfactants on bioavailability and biodegradation of polycyclic aromatic hydrocarbons.非离子表面活性剂对多环芳烃生物可利用性和生物降解性的影响。
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10
Physicochemical characterization, in vitro dissolution behavior, and pharmacodynamic studies of rofecoxib-cyclodextrin inclusion compounds. preparation and properties of rofecoxib hydroxypropyl beta-cyclodextrin inclusion complex: a technical note.罗非昔布 - 环糊精包合物的物理化学表征、体外溶出行为及药效学研究。罗非昔布羟丙基β - 环糊精包合物的制备与性质：技术说明。
AAPS PharmSciTech. 2005 Sep 20;6(1):E83-90. doi: 10.1208/pt060114.