Fukuda S, Su C, Lee T J
Experientia. 1986 Dec 1;42(11-12):1244-5. doi: 10.1007/BF01946405.
Accumulations of serotonin (5-HT) and norepinephrine (NE) were compared in control and 6-hydroxydopamine (6-OHDA) pretreated rat aorta, mesenteric and tail arteries. The distribution of these amines was corrected by subtracting tissue uptake of tritiated sorbitol in the extracellular space. 5-HT greatly accumulated both in control and 6-OHDA pretreated arteries. In contrast, NE accumulation in mesenteric and tail arteries was substantially decreased after 6-OHDA treatment. In the aorta 6-OHDA pretreatment did not affect the accumulation of both amines. These findings suggest that 5-HT accumulation in these arteries is mainly extraneuronal, and NE mainly neuronal. Since the accumulation of 5-HT in the aorta was not influenced by pretreatment with 10 microM NE, the extraneuronal uptake mechanisms for 5-HT and NE appear to be different.
在对照大鼠和经6-羟基多巴胺（6-OHDA）预处理的大鼠的主动脉、肠系膜动脉和尾动脉中，对5-羟色胺（5-HT）和去甲肾上腺素（NE）的蓄积情况进行了比较。通过减去细胞外空间中氚标记山梨醇的组织摄取量，对这些胺类的分布进行了校正。在对照动脉和经6-OHDA预处理的动脉中，5-HT均大量蓄积。相比之下，6-OHDA处理后，肠系膜动脉和尾动脉中的NE蓄积量显著降低。在主动脉中，6-OHDA预处理对两种胺类的蓄积均无影响。这些发现表明，这些动脉中5-HT的蓄积主要是神经外的，而NE主要是神经内的。由于主动脉中5-HT的蓄积不受10微摩尔NE预处理的影响，5-HT和NE的神经外摄取机制似乎不同。
