纯网织红细胞脂氧合酶生成脂氧素B
Formation of lipoxin B by the pure reticulocyte lipoxygenase.
作者信息
Kühn H, Wiesner R, Alder L, Schewe T, Stender H
出版信息
FEBS Lett. 1986 Nov 24;208(2):248-52. doi: 10.1016/0014-5793(86)81026-2.
The pure reticulocyte lipoxygenase converts 5,15-DiHETE via a lipoxygenase reaction to 5,14,15-trihydroxy-6,8,10,12-eicosatetraenoic acid (a lipoxin B isomer) as shown by GC/MS analysis of its trimethylsilyl ether. With arachidonic acid, 15-HETE and 15-HETE methyl ester this lipoxin B isomer was also formed. The results presented here indicate that pure mammalian lipoxygenases are able to form lipoxins via sequential multiple oxygenation of arachidonic acid or its hydroxy derivatives.
通过对其三甲基硅醚的气相色谱/质谱分析表明，纯网织红细胞脂氧合酶通过脂氧合酶反应将5,15 - 二氢二十碳四烯酸转化为5,14,15 - 三羟基 - 6,8,10,12 - 二十碳四烯酸（一种脂oxin B异构体）。使用花生四烯酸、15 - 羟基二十碳四烯酸和15 - 羟基二十碳四烯酸甲酯时，也会形成这种脂oxin B异构体。此处呈现的结果表明，纯哺乳动物脂氧合酶能够通过花生四烯酸或其羟基衍生物的连续多次氧化形成脂oxin。
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