Birchler James A, Veitia Reiner A
Division of Biological Sciences, University of Missouri, Columbia, MO, USA.
Institut Jacques Monod, Universite Paris Diderot, Paris, France.
Epigenet Insights. 2019 Mar 31;12:2516865719840291. doi: 10.1177/2516865719840291. eCollection 2019.
The role of genomic balance in accumulating species hybrid incompatibilities is discussed. Aneuploidy has been shown to produce more global modulations than polyploidy with the responsible genes being transcription factors and signaling components involved in molecular complexes, illustrating a stoichiometric component to gene expression. Genomic imbalance is usually detrimental to the organism and in many cases results in lethality. Here, it is proposed that once gene flow is prevented between or within populations by various speciation initiating processes, the stoichiometric relationship of members of macromolecular complexes can change via compensatory drift with the eventual result of newly established functional balances. However, when these new relationships are brought together in interspecific hybrids, detrimental consequences will occur. We suggest that these detrimental interactions contribute to hybrid incompatibilities.
讨论了基因组平衡在积累物种杂交不亲和性中的作用。已表明非整倍体比多倍体产生更多的全局调节，其相关基因是参与分子复合物的转录因子和信号成分，这说明了基因表达中的化学计量成分。基因组失衡通常对生物体有害，在许多情况下会导致致死性。在此，有人提出，一旦通过各种物种形成起始过程阻止了种群间或种群内的基因流动，大分子复合物成员的化学计量关系就会通过补偿性漂变而改变，最终结果是建立新的功能平衡。然而，当这些新关系在种间杂种中结合时，就会产生有害后果。我们认为这些有害相互作用导致了杂交不亲和性。
