Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Egypt.
Nat Prod Res. 2021 Mar;35(5):829-835. doi: 10.1080/14786419.2019.1601094. Epub 2019 Apr 10.
are used in the Egyptian folk medicine for their hypoglycemic effects. The standardized ethanolic extracts of both plants caused a significant decrease in fasting blood glucose level at two different doses (250 and 500 mg/kg) in streptozotocin-induced diabetic rats' model. Further, antioxidant activity and α-glucosidase inhibition assays were conducted as well as the measurement of insulin levels and the biomarkers for both liver and kidney functions in the treated animals. Beneficiary effects of BMLE and BVLE in the treatment of diabetes were found not to be limited to hypoglycemic effect but included preventing liver and kidney tissue damage that are associated with diabetes. A strong inhibition of the α-glucosidase enzyme by both extracts may be a contributing mechanism in the overall anti-diabetic effect that was observed. Further detailed study is needed in the future to explore the mechanism of action of both plants.
它们被用于埃及民间医学，以发挥其降血糖作用。这两种植物的标准化乙醇提取物在两种不同剂量（250 和 500mg/kg）下，均能显著降低链脲佐菌素诱导的糖尿病大鼠模型的空腹血糖水平。此外，还进行了抗氧化活性和α-葡萄糖苷酶抑制试验，以及测定了治疗动物的胰岛素水平和肝肾功能的生物标志物。BMLE 和 BVLE 在糖尿病治疗中的有益作用不仅限于降血糖作用，还包括预防与糖尿病相关的肝肾功能损害。这两种提取物对α-葡萄糖苷酶的强烈抑制可能是观察到的整体抗糖尿病作用的一个促成机制。未来还需要进一步的详细研究来探索这两种植物的作用机制。
