Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Haydapaşa, 34668, İstanbul, Turkey.
Mini Rev Med Chem. 2019;19(17):1427-1442. doi: 10.2174/1389557519666190410125910.
The process of programmed cell death in higher eukaryotes (apoptosis), is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is considered as a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced cell death. Apoptosis seems to play an important key role in the progression of several human diseases like Alzheimer's disease, Parkinson's disease and many types of cancer. Promotion of apoptosis may be a good approach for the prevention of cancer cell proliferation. In early studies, antitumor compounds have been found to induce the apoptotic process in tumor cells. On the other hand, several hydrazones were reported to have lower toxicity than hydrazides due to the blockage of -NH2 group. Therefore, the design of hydrazones that activate and promote apoptosis is an attractive strategy for the discovery and development of potential anticancer agents. The aim of this review is to provide a general overview of current knowledge and the connection between apoptosis and hydrazone. It is also the guide for the apoptotic activities of new hydrazone derivatives.
高等真核生物（细胞凋亡）程序性细胞死亡的过程通常具有独特的形态学特征和能量依赖的生化机制。细胞凋亡被认为是包括正常细胞更替、免疫系统的正常发育和功能、激素依赖性萎缩、胚胎发育和化学诱导细胞死亡在内的各种过程的重要组成部分。细胞凋亡似乎在包括阿尔茨海默病、帕金森病和多种癌症在内的几种人类疾病的进展中起着重要作用。促进细胞凋亡可能是预防癌细胞增殖的一种好方法。在早期研究中，抗肿瘤化合物被发现可诱导肿瘤细胞发生凋亡过程。另一方面，由于 -NH2 基团的阻断，一些腙类化合物的毒性比酰肼类低。因此，设计激活和促进细胞凋亡的腙类化合物是发现和开发潜在抗癌药物的一种有吸引力的策略。本文综述的目的是提供关于细胞凋亡和腙类之间联系的最新知识的概述。它也是新型腙类衍生物细胞凋亡活性的指南。
