Division of Cardiovascular Medicine, University of Southern California, Los Angeles, California.
Catheter Cardiovasc Interv. 2019 Aug 1;94(2):296-300. doi: 10.1002/ccd.28221. Epub 2019 Apr 10.
Mixed aortic valve disease refers to the combination of aortic regurgitation (AR) and aortic stenosis (AS). Commonly etiologies include a bicuspid aortic valve, rheumatic heart disease, and endocarditis superimposed upon a stenotic aortic valve. Treatment depends upon the severity of disease, the presence of symptoms and the size and function of the left ventricle. We present a case of a young patient that presented with new onset acute decompensated heart failure with mixed aortic valve disease that was successful treated with transcatheter aortic valve replacement (TAVR). Invasive hemodynamics at baseline and following TAVR provide an insight into the characteristic features of mixed aortic valve disease. TAVR represents a new treatment option for critically ill patients deemed high risk or nonoperable for surgical aortic valve replacement.
混合性主动脉瓣疾病是指主动脉瓣反流（AR）和主动脉瓣狭窄（AS）的组合。常见病因包括二叶式主动脉瓣、风湿性心脏病以及在狭窄的主动脉瓣上并发的心内膜炎。治疗取决于疾病的严重程度、症状的存在以及左心室的大小和功能。我们报告了一例年轻患者，因新发急性失代偿性心力衰竭伴混合性主动脉瓣疾病就诊，经经导管主动脉瓣置换术（TAVR）成功治疗。基线和 TAVR 后的有创血流动力学提供了对混合性主动脉瓣疾病特征的深入了解。对于因手术主动脉瓣置换风险高或不可行而被视为高危的重症患者，TAVR 代表了一种新的治疗选择。
