Desgranges Florian, Bochud Pierre-Yves, Resch Grégory
Service des maladies infectieuses, Département de médecine, CHUV et Université de Lausanne, 1011 Lausanne.
Département de microbiologie fondamentale, Université de Lausanne, 1004 Lausanne.
Rev Med Suisse. 2019 Apr 10;15(646):771-775.
Phages are viruses able to specifically infect and lyse target bacteria. The use of phages in the treatment of bacterial infections has been limited due of the development of antibiotics since the 1950's. However, phagotherapy is now gaining more interest due to the emergence of multidrug resistant bacteria. Here, we present the benefits and disadvantages of using phages versus antibiotics to treat bacterial infections and describe potential development areas for phagotherapy by reviewing current evidence.
噬菌体是能够特异性感染并裂解靶细菌的病毒。自20世纪50年代以来,由于抗生素的发展,噬菌体在治疗细菌感染方面的应用受到了限制。然而,由于多重耐药细菌的出现,噬菌体疗法现在越来越受到关注。在此,我们通过回顾当前证据,阐述使用噬菌体与抗生素治疗细菌感染的利弊,并描述噬菌体疗法的潜在发展领域。