Innemee H C, van Zwieten P A
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Aug 16;207(3):149-56. doi: 10.1007/BF00411049.
The rise in intraocular pressure (IOP) observed after the administration of clonidine into the carotid arteries was studied in anesthetized rats and cats. This increase of IOP proved to be blocked by the alpha-sympathicolytic agent piperoxane and by the muscle relaxants d-tubocurarine and gallamine. Our experiments suggest that the elevation of IOP after clonidine injection is due to contraction of the eyelids and extraocular muscles. In these tissues alpha-adrenoceptors seem to play a part.
在麻醉大鼠和猫身上研究了向颈动脉注射可乐定后眼内压（IOP）的升高情况。结果表明，α-交感神经阻滞剂哌罗克生以及肌肉松弛剂d-筒箭毒碱和加拉明可阻断这种眼内压升高。我们的实验表明，注射可乐定后眼内压升高是由于眼睑和眼外肌收缩所致。在这些组织中，α-肾上腺素能受体似乎发挥了作用。
