在 DNA 纳米笼中程序化分割 G-四链体及其在活细胞中的 microRNA 成像。
Programming a split G-quadruplex in a DNA nanocage and its microRNA imaging in live cells.
机构信息
School of Pharmacy, Nantong University, Nantong, Jiangsu 226001, China.
出版信息
Chem Commun (Camb). 2019 Apr 25;55(35):5131-5134. doi: 10.1039/c9cc02096a.
PMID:30973555
Abstract
A novel approach to program target-responsive devices by incorporating the split G4 motifs in a DNA nanocage has been developed. The rigid prism outcompetes the flexible one in reaction kinetics and signal/background ratios, which can be easily internalized by cells and successfully applied in microRNA imaging in live cells.
摘要
通过在 DNA 纳米笼中引入分裂的 G4 基序，开发了一种用于编程靶标响应器件的新方法。刚性棱柱体在反应动力学和信号/背景比方面胜过柔性棱柱体，它可以很容易被细胞内化，并成功应用于活细胞中的 microRNA 成像。
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