新型手性硫代缩氨基脲配体衍生的手性金属配合物的合成及其作为潜在抗氧化剂的研究。
Synthesis of novel chiral metal complexes derived from chiral thiosemicarbazide ligands as potential antioxidant agents.
机构信息
Faculty of Science and Arts, Department of Chemistry, Gaziantep University, Gaziantep, Turkey.
Köyceğiz Vocational School, Muğla Sıtkı Koçman University, Muğla, Turkey.
出版信息
Chirality. 2019 Jun;31(6):434-444. doi: 10.1002/chir.23069. Epub 2019 Apr 11.
Two new chiral thiosemicarbazide ligands and their Cu (II), Ni (II), Pd (II), and Zn (II) complexes were synthesized and characterized by nuclear magnetic resonance (NMR) (only for ligand), Fourier transform infrared (FT-IR), ultraviolet visible (UV-Vis), mass, and elemental analysis. The antioxidant activity of ligands and their metal complexes was examined. It was found that the antioxidant activity of metal complexes was better than their ligands. In addition, the antioxidant activity, as reflected by free radical scavenging, was evaluated. Besides, Pd (II) complexes exhibited better antioxidant activity than Ni (II), Cu (II), and Zn (II) complexes. Therefore, complexes (3a-Pd and 3b-Pd) can be used as an antioxidant agent or antioxidant test standard.
两种新的手性硫代半卡巴肼配体及其 Cu（II）、Ni（II）、Pd（II）和 Zn（II）配合物通过核磁共振（NMR）（仅针对配体）、傅里叶变换红外（FT-IR）、紫外可见（UV-Vis）、质谱和元素分析进行了合成和表征。研究了配体及其金属配合物的抗氧化活性。结果表明，金属配合物的抗氧化活性优于其配体。此外，还通过自由基清除来评估抗氧化活性。此外，Pd（II）配合物的抗氧化活性优于 Ni（II）、Cu（II）和 Zn（II）配合物。因此，配合物（3a-Pd 和 3b-Pd）可用作抗氧化剂或抗氧化测试标准。
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