深部浸润型子宫内膜异位症女性中纤维肌痛的患病率。

Prevalence of fibromyalgia among women with deep infiltrating endometriosis.

机构信息

Department of Gynecology, Institut Clínic of Gynecology, Obstetrics and Neonatology, Hospital Clínic of Barcelona, Barcelona, Spain.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

出版信息

Int J Gynaecol Obstet. 2019 Aug;146(2):157-163. doi: 10.1002/ijgo.12822. Epub 2019 May 9.

DOI:10.1002/ijgo.12822

PMID:30973964

Abstract

OBJECTIVE

To estimate the prevalence of fibromyalgia among women with endometriosis and analyze the effect of fibromyalgia on health-related quality of life (HRQoL).

METHODS

An observational case-control study conducted at a tertiary hospital in Barcelona between April 2015 and March 2017 among women with deep infiltrating endometriosis (DIE; n=80), women with superficial endometriosis or ovarian endometrioma (non-DIE; n=76), and control women without endometriosis (n=73). Fibromyalgia was assessed via the London Fibromyalgia Epidemiological Study Screening Questionnaire (LFESSQ). HRQoL was evaluated with the 36-Item Short Form (SF-36) questionnaire. The impact of fibromyalgia and other clinical characteristics was assessed by multivariate regression analysis.

RESULTS

More women fulfilled the criteria for fibromyalgia in the DIE group than in the non-DIE and control groups by LFESSQ-4 (31 [39%], 12 [16%], and 6 [8%], respectively; P=0.009) and LFESSQ-6 (22 [28%], 8 [11%], and 4 [5%], respectively; P=0.008). The DIE group reported significantly poorer HRQoL for all SF-36 dimensions. Women with DIE who fulfilled the criteria for fibromyalgia had lower physical component scores (-31.6; 95% confidence interval, -50.8 to -12.3; P=0.003).

CONCLUSION

The estimated prevalence of fibromyalgia was higher among women with DIE. Women with DIE and positive fibromyalgia screening had lower HRQoL.

摘要

目的

评估纤维肌痛在子宫内膜异位症女性中的患病率，并分析纤维肌痛对健康相关生活质量（HRQoL）的影响。

方法

2015 年 4 月至 2017 年 3 月在巴塞罗那的一家三级医院进行了一项观察性病例对照研究，纳入了患有深部浸润性子宫内膜异位症（DIE；n=80）、浅表性子宫内膜异位症或卵巢子宫内膜瘤（非 DIE；n=76）和无子宫内膜异位症的对照组女性（n=73）。通过伦敦纤维肌痛流行病学研究筛查问卷（LFESSQ）评估纤维肌痛。使用 36 项简短表格（SF-36）问卷评估 HRQoL。通过多变量回归分析评估纤维肌痛和其他临床特征的影响。

结果

通过 LFESSQ-4（分别为 31 [39%]、12 [16%]和 6 [8%]；P=0.009）和 LFESSQ-6（分别为 22 [28%]、8 [11%]和 4 [5%]；P=0.008），DIE 组中符合纤维肌痛标准的女性多于非 DIE 组和对照组。DIE 组在所有 SF-36 维度上的 HRQoL 均显著较差。符合纤维肌痛标准的 DIE 女性的生理成分评分较低（-31.6；95%置信区间，-50.8 至 -12.3；P=0.003）。