Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Department of Gynecology and Obstetrics, Peking University First Hospital, Beijing, China.
BMC Womens Health. 2018 Dec 22;18(1):205. doi: 10.1186/s12905-018-0697-7.
To compare potential factors associated with deep infiltrating endometriosis (DIE) versus ovarian endometrioma (OMA) among endometriosis patients in China.
A subgroup analysis of factors associated with DIE versus OMA was performed in Chinese women from the FEELING study. This study included 156 OMA patients and 78 DIE patients. Retrospective information on symptoms and previous medical history was collected via face-to-face interviews; patients also completed a questionnaire to provide information on current habits. Univariate and multivariate logistic regression analyses were conducted to identify potential factors that are associated with DIE versus OMA.
From univariate analysis, women who were married, at older age, had any siblings, prior pregnancy, or longer time since age at menarche on the day of visit were more likely to be diagnosed with DIE (P < 0.05). Also, the incidence of previous uterine surgery, menstrual and ovulatory disorders, deep dyspareunia, and gastrointestinal symptoms during menstruation were major factors that were significantly associated with the diagnosis of DIE (P < 0.05). Multivariate analysis showed that women with any siblings, gastrointestinal symptoms during menstruation, or eating a greater number of fruit/vegetables per day were more likely to be diagnosed with DIE. Meanwhile, eating organic food and experiencing stress were major factors that are associated with the diagnosis of OMA.
The findings provide additional information on the potential risk factors that are associated with DIE, compared with OMA among Chinese endometriosis patients. The results may help to better understand DIE versus OMA, and aid in earlier risk stratification and diagnosis of the patients.
NCT01351051 . Registered 10 May 2011.
本研究旨在比较中国子宫内膜异位症患者中深部浸润型子宫内膜异位症（DIE）与卵巢子宫内膜异位囊肿（OMA）相关的潜在因素。
FEELING 研究中的中国子宫内膜异位症患者亚组分析了 DIE 与 OMA 相关的因素。该研究纳入了 156 例 OMA 患者和 78 例 DIE 患者。通过面对面访谈收集症状和既往病史的回顾性信息；患者还完成了一份问卷，提供当前习惯的信息。采用单因素和多因素逻辑回归分析来确定与 DIE 与 OMA 相关的潜在因素。
单因素分析显示，已婚、年龄较大、有兄弟姐妹、既往妊娠或初潮后时间较长的患者更有可能被诊断为 DIE（P<0.05）。此外，既往子宫手术、月经和排卵障碍、深部性交痛和经期胃肠道症状是与 DIE 诊断显著相关的主要因素（P<0.05）。多因素分析显示，有兄弟姐妹、经期胃肠道症状或每天食用更多水果/蔬菜的女性更有可能被诊断为 DIE。同时，食用有机食品和经历压力是与 OMA 诊断相关的主要因素。
与中国子宫内膜异位症患者的 OMA 相比，这些发现提供了与 DIE 相关的潜在危险因素的额外信息。研究结果可能有助于更好地理解 DIE 与 OMA，并有助于对患者进行更早的风险分层和诊断。
NCT01351051。注册于 2011 年 5 月 10 日。
