嘧啶和环三核苷酸加入第二信使交响乐。
Pyrimidines and Cyclic Trinucleotides Join the Second Messenger Symphony.
机构信息
Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, USA.
Department of Microbiology & Molecular Genetics, Michigan State University, East Lansing, MI, USA.
出版信息
Cell Host Microbe. 2019 Apr 10;25(4):471-473. doi: 10.1016/j.chom.2019.03.016.
Abstract
In recent work, Whiteley et al. (2019) define a family of bacterial nucleotidyltransferases (CD-NTases) capable of synthesizing pyrimidine containing cyclic dinucleotides and cyclic trinucleotides. CD-NTases are broadly distributed across bacterial phyla, suggesting that they play important roles in bacterial physiology and modulation of the metazoan host innate immune system.
摘要
在最近的研究中，Whiteley 等人（2019 年）定义了一族能够合成嘧啶环二核苷酸和环三核苷酸的细菌核苷酸转移酶（CD-NTases）。CD-NTases 在细菌门中广泛分布，这表明它们在细菌生理学和调节后生动物宿主固有免疫系统方面发挥着重要作用。
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