Lv Ziyu, Chen Zhonghui, Shao Kenan, Qing Guangyan, Sun Taolei
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.
School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.
Polymers (Basel). 2016 Aug 18;8(8):310. doi: 10.3390/polym8080310.
Helical structure is a sophisticated ubiquitous motif found in nature, in artificial polymers, and in supramolecular assemblies from microscopic to macroscopic points of view. Significant progress has been made in the synthesis and structural elucidation of helical polymers, nevertheless, a new direction for helical polymeric materials, is how to design smart systems with controllable helical chirality, and further use them to develop chiral functional materials and promote their applications in biology, biochemistry, medicine, and nanotechnology fields. This review summarizes the recent progress in the development of high-performance systems with tunable helical chirality on receiving external stimuli and discusses advances in their applications as drug delivery vesicles, sensors, molecular switches, and liquid crystals. Challenges and opportunities in this emerging area are also presented in the conclusion.
从微观到宏观的角度来看，螺旋结构是一种在自然界、人工聚合物以及超分子组装体中普遍存在的复杂基序。尽管在螺旋聚合物的合成和结构解析方面已经取得了重大进展，然而，螺旋聚合物材料的一个新方向是如何设计具有可控螺旋手性的智能体系，并进一步利用它们开发手性功能材料，促进其在生物学、生物化学、医学和纳米技术领域的应用。本综述总结了在开发受外部刺激时具有可调螺旋手性的高性能体系方面的最新进展，并讨论了它们作为药物递送囊泡、传感器、分子开关和液晶的应用进展。结论部分还介绍了这一新兴领域面临的挑战和机遇。
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