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离子介导的构象转换。

Ion-mediated conformational switches.

作者信息

Knipe Peter C, Thompson Sam, Hamilton Andrew D

机构信息

Department of Chemistry , Chemistry Research Laboratory , University of Oxford , 12 Mansfield Road , Oxford OX1 3TA , UK . Email:

出版信息

Chem Sci. 2015 Mar 1;6(3):1630-1639. doi: 10.1039/c4sc03525a. Epub 2014 Nov 21.

DOI:10.1039/c4sc03525a
PMID:28694943
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5482205/
Abstract

Molecular switches are ubiquitous in Nature and provide the basis of many forms of transport and signalling. synthetic molecules that change conformation, and thus function, reversibly in a stimulus-dependent manner are of great interest not only to chemists but society in general; myriad applications exist in storage, display, sensing and medicine. Here we describe recent developments in the area of -mediated switching.

摘要

分子开关在自然界中无处不在,是多种运输和信号传导形式的基础。能够以刺激依赖的方式可逆地改变构象进而改变功能的合成分子不仅引起了化学家的极大兴趣,也受到了整个社会的广泛关注;在存储、显示、传感和医学等领域有着无数的应用。在此,我们描述了在介导开关领域的最新进展。

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3
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4
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6
Formation of supramolecular channels by reversible unwinding-rewinding of bis(indole) double helix via ion coordination.通过离子配位可逆解旋-重绕双吲哚双链形成超分子通道。
Nat Commun. 2022 Oct 31;13(1):6507. doi: 10.1038/s41467-022-34159-y.
7
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8
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10
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Chem Sci. 2020 Feb 4;11(10):2790-2795. doi: 10.1039/c9sc06197e.
Org Biomol Chem. 2014 Oct 28;12(40):7937-41. doi: 10.1039/c4ob01556h.
4
Redox-dependent conformational switching of diphenylacetylenes.二苯乙炔的氧化还原依赖性构象转换
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5
Conversion of light into macroscopic helical motion.将光转换为宏观螺旋运动。
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6
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8
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