Salinas Jennifer J, Roy Renet, Dwivedi Alok K, Shokar Navkiran K
1 Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.
Hisp Health Care Int. 2019 Sep;17(3):118-124. doi: 10.1177/1540415319837850. Epub 2019 Apr 12.
This article describes the risk of hereditary breast cancer (HBC) in low-income Hispanic women living on the U.S.-Mexico border using the Pedigree Assessment Tool (PAT).
The PAT was administered as part of the El Paso and Hudspeth County Breast Cancer Education, Screening and NavigaTion program (BEST). Baseline data ( = 1,966) from this program was used to analyze risk factors for HBC. Analysis was conducted to determine significant covariates associated with the presence of any PAT risk factors.
The PAT identified 17% (95% CI [15%, 19%]) of the women in the study as having some risk of HBC. Having had a mammogram within 3 years was significantly associated with having any PAT risk factors (odds ratio [OR] = 1.79, = .006). Women who immigrated to the United States during childbearing age (OR = 0.610, = .009) or during peri/menopause (OR = 0.637, = .024) were significantly less likely to have any PAT risk factors.
The PAT instrument detected a substantial pool of women who may be at risk for HBC. A significant proportion of these women were not up to date mammogram.
The PAT is an effective tool to identify women at risk for HBC and encourage regular screening.
本文使用家系评估工具（PAT）描述了生活在美国 - 墨西哥边境的低收入西班牙裔女性患遗传性乳腺癌（HBC）的风险。
PAT作为埃尔帕索和赫德斯佩斯县乳腺癌教育、筛查与导航项目（BEST）的一部分进行管理。该项目的基线数据（n = 1,966）用于分析HBC的风险因素。进行分析以确定与任何PAT风险因素存在相关的显著协变量。
PAT确定研究中的17%（95%可信区间[15%，19%]）的女性有患HBC的风险。在3年内进行过乳房X光检查与有任何PAT风险因素显著相关（优势比[OR]=1.79，P = 0.006）。在育龄期移民到美国的女性（OR = 0.610，P = 0.009）或在围绝经期/绝经期间移民到美国的女性（OR = 0.637，P = 0.024）有任何PAT风险因素的可能性显著降低。
PAT工具检测出大量可能有HBC风险的女性。这些女性中有很大一部分没有进行最新的乳房X光检查。
PAT是识别有HBC风险的女性并鼓励定期筛查的有效工具。
