Schäfer Rebecca J B, Aronoff Matthew R, Wennemers Helma
Laboratorium für Organische Chemie, ETH Zurich, D-CHAB, Vladimir-Prelog-Weg 3, CH-8093 Zürich, SCS-DSM Award for best poster presentation in Chemical Biology.
Laboratorium für Organische Chemie, ETH Zurich, D-CHAB, Vladimir-Prelog-Weg 3, CH-8093 Zürich.
Chimia (Aarau). 2019 Apr 24;73(4):308-312. doi: 10.2533/chimia.2019.308.
The ability to selectively perform chemical reactions within living systems has transformed the field of Chemical Biology. These chemoselective processes have had a major scientific impact by enabling studies of cellular processes, producing tools for the ligations of large biomolecules, and advancing our ability to image or track small molecular changes such as posttranslational modifications. As more investigators become involved in the development and application of chemical reactions performed within complex biological settings, there have been a rising number of innovations that create improved tools and resources for understanding nature. This perspective highlights some recent achievements that show how innovation and creativity can provide new opportunities in this exciting and rapidly expanding area of chemical research.
在生命系统中选择性地进行化学反应的能力已经改变了化学生物学领域。这些化学选择性过程通过促进细胞过程研究、生产用于连接大型生物分子的工具以及提高我们对诸如翻译后修饰等小分子变化进行成像或追踪的能力，产生了重大的科学影响。随着越来越多的研究人员参与到在复杂生物环境中进行的化学反应的开发和应用中，涌现出了越来越多的创新成果，这些创新为理解自然创造了更好的工具和资源。本视角突出了一些近期的成就，展示了创新和创造力如何能在这个令人兴奋且迅速发展的化学研究领域提供新的机遇。
