复发性展神经麻痹与低磷酸酯酶症综合征
Recurrent abducens nerve palsy and hypophosphatasia syndrome.
作者信息
Khade Neha, Carrivick Simon, Orr Carolyn, Prentice David
机构信息
Department of Neurology, Royal Perth Hospital, Perth, Western Australia, Australia.
Department of Biochemistry, PathWest Laboratory Medicine Western Australia, Nedlands, Australian Capital Territory, Australia.
出版信息
BMJ Case Rep. 2019 Apr 11;12(4):e226895. doi: 10.1136/bcr-2018-226895.
Abstract
A 47-year-old woman presented with six episodes of horizontal binocular double vision over a 2-year period. CT imaging was significant for extensive dural calcification in the spine and calcification of the skull base, likely involving Dorello's canal. Biochemical testing revealed a persistently low alkaline phosphatase level. Recurrent nerve palsy may possibly be induced by mechanical compression of the sixth cranial nerve in Dorello's canal from calcification due to hypophosphatasia syndrome.
摘要
一名47岁女性在2年时间里出现了6次水平性双眼复视发作。CT成像显示脊柱有广泛的硬脑膜钙化以及颅底钙化，可能累及Dorello管。生化检测显示碱性磷酸酶水平持续偏低。复发性神经麻痹可能是由于低磷酸酯酶症综合征导致钙化，进而机械性压迫Dorello管内的第六颅神经所致。
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