建立先天性膈疝和气管闭塞兔模型的手术技术。

Surgical technique for developing a rabbit model of congenital diaphragmatic hernia and tracheal occlusion.

作者信息

Mudri M, Smith S A, Vander Tuin C, Davidson J, Regnault T R H, Bütter A

机构信息

Division of General Surgery, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

Departments of Obstetrics & Gynaecology and Physiology & Pharmacology, Schulich School of Medicine, Western University, London, ON, Canada.

出版信息

MethodsX. 2019 Mar 22;6:594-600. doi: 10.1016/j.mex.2019.03.001. eCollection 2019.

DOI:10.1016/j.mex.2019.03.001

PMID:30976533

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6441759/

Abstract

The surgical model of congenital diaphragmatic hernia (CDH) has been utilized in exploring treatments and innovative therapies, such as tracheal occlusion (TO). The rabbit is an excellent surgical model compared to others due to lower cost, ease of care, short gestational period, and large litter size. This model is also ideal in studying lung hypoplasia of CDH because rabbit lung development is most similar to humans as alveolarization begins prior to birth and continues post-natally. However, the surgical technique in creating a rabbit model of CDH is quite difficult and information is lacking on how to establish this model. Therefore, the aim of this paper is to describe: •Surgical technique in establishing a rabbit model of CDH and TO•Perioperative care for pregnant rabbit does.

摘要

先天性膈疝（CDH）的手术模型已被用于探索治疗方法和创新疗法，如气管闭塞（TO）。与其他动物相比，兔子是一种优秀的手术模型，因为其成本较低、易于照料、妊娠期短且产仔数多。该模型在研究CDH的肺发育不全方面也很理想，因为兔子的肺发育与人类最为相似，肺泡化在出生前就开始，并在出生后继续进行。然而，创建CDH兔子模型的手术技术相当困难，并且缺乏关于如何建立该模型的信息。因此，本文的目的是描述：•建立CDH和TO兔子模型的手术技术•孕兔的围手术期护理。