妊娠期高血压疾病会增加日后患年龄相关性黄斑变性新生血管型的风险。
Hypertensive disorders of pregnancy increase the risk of developing neovascular age-related macular degeneration in later life.
作者信息
Curtin Karen, Theilen Lauren H, Fraser Alison, Smith Ken R, Varner Michael W, Hageman Gregory S
机构信息
a Department of Internal Medicine , University of Utah School of Medicine , Salt Lake City , USA.
b Pedigree and Population Resource, Huntsman Cancer Institute , University of Utah , Salt Lake City , USA.
出版信息
Hypertens Pregnancy. 2019 Aug;38(3):141-148. doi: 10.1080/10641955.2019.1597107. Epub 2019 Apr 12.
Abstract
: Hypertensive disorders of pregnancy (HDP) and short-term adverse outcomes have long been recognized; however, survivors remain at risk of long-term complications. We investigated whether HDP is associated with the development of choroidal neovascular age-related macular degeneration (CNV AMD). : We identified 31,454 women who experienced HDP based on Utah birth certificates and 62,908 unexposed women matched 2:1 to the exposed. Risk of CNV AMD was estimated using Cox models. : Women with HDP exhibited an 80% higher risk for early CNV AMD (age < 70 y; 95%CI 1.23-2.58). : Our findings may have implications forearlier CNV AMD screening and detection.
摘要
妊娠高血压疾病（HDP）与短期不良结局早已为人所知；然而，幸存者仍有长期并发症的风险。我们调查了HDP是否与年龄相关性黄斑变性脉络膜新生血管（CNV AMD）的发生有关。我们根据犹他州出生证明确定了31454名患有HDP的女性，并以2:1的比例匹配了62908名未暴露的女性作为对照。使用Cox模型估计CNV AMD的风险。患有HDP的女性发生早期CNV AMD（年龄<70岁）的风险高出80%（95%CI 1.23 - 2.58）。我们的研究结果可能对早期CNV AMD的筛查和检测具有启示意义。
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