Curtin Karen, Theilen Lauren H, Fraser Alison, Smith Ken R, Varner Michael W, Hageman Gregory S
a Department of Internal Medicine , University of Utah School of Medicine , Salt Lake City , USA.
b Pedigree and Population Resource, Huntsman Cancer Institute , University of Utah , Salt Lake City , USA.
Hypertens Pregnancy. 2019 Aug;38(3):141-148. doi: 10.1080/10641955.2019.1597107. Epub 2019 Apr 12.
: Hypertensive disorders of pregnancy (HDP) and short-term adverse outcomes have long been recognized; however, survivors remain at risk of long-term complications. We investigated whether HDP is associated with the development of choroidal neovascular age-related macular degeneration (CNV AMD). : We identified 31,454 women who experienced HDP based on Utah birth certificates and 62,908 unexposed women matched 2:1 to the exposed. Risk of CNV AMD was estimated using Cox models. : Women with HDP exhibited an 80% higher risk for early CNV AMD (age < 70 y; 95%CI 1.23-2.58). : Our findings may have implications forearlier CNV AMD screening and detection.
妊娠高血压疾病（HDP）与短期不良结局早已为人所知；然而，幸存者仍有长期并发症的风险。我们调查了HDP是否与年龄相关性黄斑变性脉络膜新生血管（CNV AMD）的发生有关。我们根据犹他州出生证明确定了31454名患有HDP的女性，并以2:1的比例匹配了62908名未暴露的女性作为对照。使用Cox模型估计CNV AMD的风险。患有HDP的女性发生早期CNV AMD（年龄<70岁）的风险高出80%（95%CI 1.23 - 2.58）。我们的研究结果可能对早期CNV AMD的筛查和检测具有启示意义。
