Bilal Muhammad Humayun, Prehm Marko, Njau Andrew Efraim, Samiullah Muhammad Haris, Meister Annette, Kressler Jörg
Department of Chemistry, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany.
Polymers (Basel). 2016 Mar 16;8(3):80. doi: 10.3390/polym8030080.
Biodegradable and hydrophilic functional polyesters were synthesized enzymatically using xylitol or d-sorbitol together with divinyl adipate and lipase B from (CAL-B). The resulting polyesters had pendant OH-groups from their sugar units which were esterified to different degrees with stearic acid chloride. The structure and the degrees of polymerization of the resulting graft copolymers based on poly(xylitol adipate) and poly(d-sorbitol adipate) were characterized by ¹H NMR spectroscopy and SEC. DSC, WAXS and SAXS measurements indicated that a phase separation between polymer backbone and stearoyl side chains occurred in the graft copolymers, and, additionally, the side chains were able to crystallize which resulted in the formation of a lamellar morphology. Additionally, nanoparticles of the graft copolymers in an aqueous environment were studied by DLS and negative stain TEM.
使用木糖醇或d-山梨醇与己二酸二乙烯酯以及来自南极假丝酵母的脂肪酶B（CAL-B）通过酶法合成了可生物降解且亲水性的功能性聚酯。所得聚酯具有来自其糖单元的侧链羟基，这些羟基与硬脂酰氯发生了不同程度的酯化反应。通过¹H NMR光谱和尺寸排阻色谱（SEC）对基于聚（木糖醇己二酸酯）和聚（d-山梨醇己二酸酯）的接枝共聚物的结构和聚合度进行了表征。差示扫描量热法（DSC）、广角X射线散射（WAXS）和小角X射线散射（SAXS）测量表明，接枝共聚物中聚合物主链和硬脂酰侧链之间发生了相分离，此外，侧链能够结晶，从而形成了层状形态。此外，通过动态光散射（DLS）和负染色透射电子显微镜（TEM）研究了接枝共聚物在水性环境中的纳米颗粒。
