Fuller R W, Snoddy H D, Clemens J A
Endocr Res Commun. 1978;5(2):161-71. doi: 10.3109/07435807809089015.
Quipazine, a serotonin receptor agonist, increased serum corticosterone within 30 min after its i.p. injection (at 10 mg/kg) into rats; the effect persisted at 1 and 2 hrs, but not at 4 hrs. Elevation of serum corticosterone did not occur with a 1.25 mg/kg dose of quipazine but was dose-related over a 2.5-20 mg/kg dose range. The effect of quipazine was completely prevented by methergoline, a serotonin receptor antagonist. The effect of quipazine was present in rats pretreated with 5,7-dihydroxytryptamine to destroy serotonin nerves and was not enhanced (as was the effect of L-5-hydroxytryptophan) by fluoxetine pretreatment. These data are compatible with the idea that quipazine increases serum corticosterone as a consequence of direct stimulation of serotonin receptors in brain.
喹哌嗪是一种血清素受体激动剂，经腹腔注射（剂量为10毫克/千克）到大鼠体内后，在30分钟内即可使血清皮质酮水平升高；这种作用在1小时和2小时时仍然存在，但在4小时时消失。1.25毫克/千克剂量的喹哌嗪不会引起血清皮质酮水平升高，但在2.5至20毫克/千克的剂量范围内，其作用与剂量相关。血清素受体拮抗剂麦角新碱可完全阻止喹哌嗪的这种作用。在用5,7 - 二羟基色胺预处理以破坏血清素神经的大鼠中，喹哌嗪的作用仍然存在，并且氟西汀预处理不会增强（像L - 5 - 羟色氨酸那样）其作用。这些数据与以下观点相符：喹哌嗪通过直接刺激大脑中的血清素受体而增加血清皮质酮水平。
