Centre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, China.
Department of Public Health and Preventive Medicine, Chang Zhi Medical college, Chang Zhi, Shan Xi, China.
Biol Trace Elem Res. 2020 Feb;193(2):326-333. doi: 10.1007/s12011-019-01716-4. Epub 2019 Apr 14.
It is uncertain how many factors affect urinary iodine concentration. The aim of this study was to determine the effect of consumption of drinking water with high iodine concentration on urinary iodine concentration in pregnant and lactating women, and infants. We included 218 lactating women and their infants and 142 pregnant women in areas with suitable and high water iodine content. Urine, serum, and water iodine concentration were assessed. Breastfeeding women living in areas with high water iodine content had a greater likelihood of iodine sufficiency or iodine excess [odds ratio (P = 0.044, P < 0.001)] compared with women living in areas with suitable water iodine content. Older women were less likely to have higher urinary iodine concentration (P = 0.041). Pregnant women who consumed milk > 4 times weekly during pregnancy were more likely to be iodine sufficient (P = 0.028). Living in areas with high water iodine content for > 5 years is a risk factor for iodine excess (P < 0.001, P = 0.007). There is a probability of higher urinary iodine concentration in pregnant and lactating women and their infants living in areas with high water iodine content. Age had an effect on iodine excess in lactating women. Consumption of milk > 4 times a week during pregnancy and living in an area with high iodine water content for > 5 years were associated with iodine sufficiency and iodine excess in pregnant women.
目前尚不清楚有多少因素会影响尿碘浓度。本研究旨在确定饮用水中高碘浓度对孕妇和哺乳期妇女及其婴儿尿碘浓度的影响。我们纳入了 218 名哺乳期妇女及其婴儿和 142 名生活在水碘适宜和高碘地区的孕妇。评估了尿碘、血清碘和水碘浓度。与生活在水碘适宜地区的妇女相比，生活在高水碘地区的哺乳期妇女碘充足或碘过量的可能性更大[比值比（P=0.044，P<0.001）]。年龄较大的妇女尿碘浓度较低的可能性较小（P=0.041）。孕期每周饮用牛奶>4 次的孕妇更有可能碘充足（P=0.028）。生活在高水碘地区>5 年是碘过量的危险因素（P<0.001，P=0.007）。生活在高水碘地区的孕妇、哺乳期妇女及其婴儿尿碘浓度升高的可能性较大。年龄对哺乳期妇女的碘过量有影响。孕期每周饮用牛奶>4 次和生活在高碘水地区>5 年与孕妇碘充足和碘过量有关。
