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Wistar大鼠和Wistar京都大鼠乳汁中游离氨基酸浓度的差异。

Differences in free amino acid concentrations in milk between Wistar and Wistar Kyoto rats.

作者信息

Hamada Mizuki, Ihara Tsubasa, Furuse Mitsuhiro

机构信息

Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan.

出版信息

J Vet Med Sci. 2019 Jun 6;81(6):838-845. doi: 10.1292/jvms.19-0064. Epub 2019 Apr 15.

DOI:10.1292/jvms.19-0064
PMID:30982807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6612506/
Abstract

Wistar Kyoto (WKY) rats, an animal depression model, display abnormal behaviors such as hypoactivity and depression-like behavior compared with Wistar (WIS) rats as a control. A previous study confirmed a dysfunction of amino acid metabolism in the brain of WKY rats compared with that of WIS rats. At the neonatal stage, free amino acids in milk are important nutrients because they act as immediate nutrients for offspring and may affect later health and behavior of the offspring. Therefore, the present study aimed to investigate free amino acid concentrations in milk and the relationships between free amino acid concentrations in milk and plasma in WIS and WKY rats. The concentrations of ten of the determined free amino acids in milk were significantly higher, but only L-methionine was significantly lower, in WKY rats. Six free amino acids had significantly higher concentrations in colostrum and two free amino acids had higher concentrations in matured milk. Free amino acid concentrations in plasma changed by both genetic background and lactation stage; however, the patterns of change in most free amino acid concentrations except for taurine in plasma were similar between WIS and WKY rats. The transport ratio of free amino acids from plasma to milk was not similar among the free amino acids tested, and each free amino acid was influenced by the genetic background and/or the type of milk.

摘要

Wistar Kyoto（WKY）大鼠是一种动物抑郁模型，与作为对照的Wistar（WIS）大鼠相比，表现出诸如活动减退和抑郁样行为等异常行为。先前的一项研究证实，与WIS大鼠相比，WKY大鼠大脑中的氨基酸代谢存在功能障碍。在新生阶段，牛奶中的游离氨基酸是重要的营养物质，因为它们是后代的直接营养来源，可能会影响后代日后的健康和行为。因此，本研究旨在调查WIS和WKY大鼠乳汁中的游离氨基酸浓度以及乳汁和血浆中游离氨基酸浓度之间的关系。WKY大鼠乳汁中所测定的十种游离氨基酸中的几种浓度显著更高，但只有L-蛋氨酸显著更低。六种游离氨基酸在初乳中的浓度显著更高，两种游离氨基酸在成熟乳中的浓度更高。血浆中的游离氨基酸浓度因遗传背景和泌乳阶段而异；然而，除牛磺酸外，WIS和WKY大鼠血浆中大多数游离氨基酸浓度的变化模式相似。所测试的游离氨基酸从血浆到乳汁的转运率并不相同，并且每种游离氨基酸都受到遗传背景和/或乳汁类型的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1360/6612506/3625db94e69c/jvms-81-838-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1360/6612506/ff4d2b07ca8d/jvms-81-838-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1360/6612506/57f577fa7483/jvms-81-838-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1360/6612506/a599dbaacd4e/jvms-81-838-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1360/6612506/ba658d87df90/jvms-81-838-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1360/6612506/3625db94e69c/jvms-81-838-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1360/6612506/ff4d2b07ca8d/jvms-81-838-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1360/6612506/57f577fa7483/jvms-81-838-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1360/6612506/a599dbaacd4e/jvms-81-838-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1360/6612506/ba658d87df90/jvms-81-838-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1360/6612506/3625db94e69c/jvms-81-838-g005.jpg

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