Department of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.
Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.
J Biomed Mater Res A. 2019 Aug;107(8):1771-1778. doi: 10.1002/jbm.a.36696. Epub 2019 Apr 25.
Polydimethylsiloxane-based polyurethane (PU)/crystalline nanocellulose (CNC) bionanocomposites were produced via in situ prepolymer approach. Also, hexamethylene diisocyanate as aliphatic diisocyanate monomer and 1,4-butanediol as aliphatic chain extender were used. CNC was incorporated into PU matrix to prepare different PU/CNC bionanocomposites. Effect of CNC content on the properties of the bionanocomposites such as thermal, thermophysical, microstructure, and in vitro cytotoxicity was investigated. According to the results, incorporating CNCs into PU matrix significantly affected the hydrogen bonding between different microstructures of matrix. Adding different amounts of CNCs affected the thermal and thermophysical properties of bionanocomposites. Also, higher amounts of CNCs resulted in lower crystallization of hard segment. Neat PU matrix showed a moderate cytotoxicity behavior against human fibroblast cells. However, incorporating CNCs significantly improved the cytotoxicity behavior of bionanocomposites where by addition of 2 wt % of CNCs, cell viability increased to 90-100%. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1771-1778, 2019.
基于聚二甲基硅氧烷的聚氨酯（PU）/结晶纳米纤维素（CNC）生物纳米复合材料是通过原位预聚物方法制备的。此外，还使用了六亚甲基二异氰酸酯作为脂肪族二异氰酸酯单体和 1,4-丁二醇作为脂肪族扩链剂。将 CNC 掺入到 PU 基体中以制备不同的 PU/CNC 生物纳米复合材料。研究了 CNC 含量对生物纳米复合材料的性能（如热性能、热物理性能、微观结构和体外细胞毒性）的影响。结果表明，将 CNC 掺入 PU 基体中会显著影响基体不同微观结构之间的氢键。添加不同量的 CNC 会影响生物纳米复合材料的热性能和热物理性能。此外，较高含量的 CNC 会导致硬段结晶降低。纯 PU 基体对人成纤维细胞表现出中等的细胞毒性行为。然而，掺入 CNC 会显著改善生物纳米复合材料的细胞毒性行为，其中添加 2wt%的 CNC 时，细胞活力增加到 90-100%。©2019WileyPeriodicals，Inc。J Biomed Mater Res Part A：107A：1771-1778，2019。
