瑞典南部一组青少年中的IgE致敏情况及其与过敏症状的关系。

IgE sensitization in a cohort of adolescents in southern Sweden and its relation to allergic symptoms.

作者信息

Sterner Therese, Uldahl Ada, Svensson Åke, Borres Magnus P, Sjölander Sigrid, Tunsäter Alf, Björk Jonas, Svedman Cecilia, Bruze Magnus, von Kobyletzki Laura, Kiotseridis Hampus

机构信息

1Department of Dermatology, Skåne University Hospital, Jan Waldenströmsgata 16, 205 02 Malmö, Sweden.

2Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Malmö, Sweden.

出版信息

Clin Mol Allergy. 2019 Apr 2;17:6. doi: 10.1186/s12948-019-0110-6. eCollection 2019.

DOI:10.1186/s12948-019-0110-6

PMID:30983886

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6444864/

Abstract

BACKGROUND

There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is found among individuals without allergy-related diseases. The aim of this study was to analyse the sensitization profile in a representative sample of the population, and to relate patterns of allergens and allergen components to allergic symptoms.

METHODS

A population of 195 adolescents took part in this clinical study, which included a self-reported questionnaire and in vitro IgE testing.

RESULTS

Sensitization to airborne allergens was significantly more common than sensitization to food allergens, 43% vs. 14%, respectively. IgE response was significantly higher in airborne allergens among adolescents with rhinitis (p < 0.001) and eczema (p < 0.01). Among 53 children with allergic symptoms according to the questionnaire, 60% were sensitized. Sensitization to food allergens was found among those with rhinitis, but only to PR-10 proteins. None of the participants had IgE to seed storage proteins.

CONCLUSION

The adolescents in this study, taken from a normal Swedish population, were mainly sensitized to grass pollen and rarely to specific food allergens. The major grass pollen allergen Phl p 1 was the main sensitizer, followed by Cyn d 1 and Phl p 2. Sixty-one percent reporting any allergic symptom were sensitized, and the allergen components associated with wheeze and rhinoconjunctivitis were Fel d 4, Der f 2 and Can f 5.

摘要

背景

IgE致敏与过敏、喘息、湿疹及食物过敏之间存在强烈且一致的关联。在未致敏的人群中也发现了这些情况，且在无过敏相关疾病的个体中也存在致敏现象。本研究的目的是分析具有代表性的人群样本中的致敏情况，并将过敏原及过敏原成分模式与过敏症状相关联。

方法

195名青少年参与了这项临床研究，其中包括一份自我报告问卷和体外IgE检测。

结果

对空气传播过敏原的致敏显著比食物过敏原致敏更为常见，分别为43%和14%。在患有鼻炎（p < 0.001）和湿疹（p < 0.01）的青少年中，空气传播过敏原的IgE反应显著更高。根据问卷，在53名有过敏症状的儿童中，60%呈致敏状态。在鼻炎患者中发现了对食物过敏原的致敏，但仅针对PR - 10蛋白。没有参与者对种子储存蛋白有IgE反应。