Kowar Jan, Stenport Victoria, Nilsson Mats, Jemt Torsten
Prosthodontist, Brånemark Clinic, Public Dental Health Care Service, Gothenburg, Västra Götaland, Sweden.
Associate Professor, Department of Prosthetic Dentistry/Dental Material Science, The Sahlgrenska Academy at Göteborg University, Gothenburg, Sweden.
Int J Dent. 2019 Mar 11;2019:7315081. doi: 10.1155/2019/7315081. eCollection 2019.
Previous research has reported an association between tooth loss and patient mortality, while the cause of death has not been elucidated.
The purpose was to describe and compare the cause of death in implant patients treated consecutively in the edentulous arch with a reference population.
Altogether, 3902 patients were included between 1986 and 2014. Data on the causes of death for deceased patients were compared to the Swedish National Cause of Death Register for a comparable time period. Standardised mortality ratios (SMRs) were calculated based on gender and age and tested for statistical significance.
Most deceased patients (2,098) died from diseases in the circulatory system (CVD; 42%) and from cancers (26%). SMR indicated a generally increased mortality (total group) compared to the reference population during inclusion ( < 0.05; 1986-2014). Patients treated early (1986-1996) showed a lower SMR compared to patients treated later ( < 0.05; 1997-2014) especially related to CVDs. Younger patients (<60 years at surgery) showed an increased mortality due to CVDs when treated late (1997-2014; SMR = 5.4, < 0.05). Elderly patients (>79 years at surgery) showed a significantly lower mortality in almost all observed causes of death (1986-2014; < 0.05) with also a significantly lower mortality due to CVDs during the early period (1986-1996; SMR = 0.3, < 0.05).
An overall increased mortality was observed for the edentulous implant patient compared to the reference population. Elderly patients (>79 years) showed significantly lower mortality for all causes of death independent of the time period of implant surgery. Younger patients (<60 years) present an increased risk for early mortality related to CVD. SMR for all causes of death increased for patients treated late (1997-2014) as compared to patients treated early (1986-1996).
先前的研究报告了牙齿缺失与患者死亡率之间的关联，但死亡原因尚未阐明。
目的是描述和比较在无牙颌连续接受种植治疗的患者与参考人群的死亡原因。
1986年至2014年共纳入3902例患者。将已故患者的死亡原因数据与瑞典国家死亡原因登记处同期数据进行比较。根据性别和年龄计算标准化死亡率（SMR），并进行统计学显著性检验。
大多数已故患者（2098例）死于循环系统疾病（CVD；42%）和癌症（26%）。SMR表明，与纳入期间的参考人群相比，总体死亡率普遍升高（<0.05；1986 - 2014年）。早期治疗的患者（1986 - 1996年）与晚期治疗的患者相比，SMR较低（<0.05；1997 - 2014年），尤其是与CVD相关的情况。年轻患者（手术时<60岁）晚期治疗时（1997 - 2014年；SMR = 5.4，<0.05）因CVD导致的死亡率增加。老年患者（手术时>79岁）在几乎所有观察到的死亡原因中死亡率显著较低（1986 - 2014年；<0.05），早期（1986 - 1996年）因CVD导致的死亡率也显著较低（SMR = 0.3，<0.05）。
与参考人群相比，无牙颌种植患者总体死亡率增加。老年患者（>79岁）无论种植手术时间如何，所有死亡原因的死亡率均显著较低。年轻患者（<60岁）早期死于CVD的风险增加。与早期治疗的患者（1986 - 1996年）相比，晚期治疗的患者（1997 - 2014年）所有死亡原因的SMR均增加。
