Pezzi Mario, Giglio Anna Maria, Scozzafava Annamaria, Serafino Giuseppe, Maglio Pietro, Verre Mario
Department of Intensive Care, "Pugliese-Ciaccio" General Hospital, Catanzaro, Italy.
SAGE Open Med Case Rep. 2019 Apr 3;7:2050313X19839529. doi: 10.1177/2050313X19839529. eCollection 2019.
Traumatic rhabdomyolysis is a clinical and biological syndrome secondary to lysis of striated muscle fibers resulting in extended musculoskeletal damage. An acute muscle damage causes the release of constituent elements of the sarcoplasmic reticulum, such as muscle enzymes, potassium, and myoglobin in plasma circulation; these conditions are at great risk of dangerous systemic complications for life such as hypovolemic shock, hyperkalemia, and acute kidney injury. We describe the case of a patient who suffered a severe musculoskeletal and vascular trauma with elevated creatine kinase values and myoglobinemia treated early with coupled plasma filtration adsorption in order to prevent kidney damage, associated with volume replacement, loop diuretics, and correction of metabolic acidosis.
创伤性横纹肌溶解症是一种临床和生物学综合征，继发于横纹肌纤维溶解，导致广泛的肌肉骨骼损伤。急性肌肉损伤会导致肌浆网的组成成分释放到血浆循环中，如肌肉酶、钾和肌红蛋白；这些情况极易引发危及生命的全身性并发症，如低血容量性休克、高钾血症和急性肾损伤。我们描述了一例患者的病例，该患者遭受了严重的肌肉骨骼和血管创伤，肌酸激酶值升高且存在肌红蛋白尿血症，早期接受了血浆滤过吸附联合治疗以预防肾损伤，并进行了容量补充、使用袢利尿剂以及纠正代谢性酸中毒。
