Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA.
Eye Contact Lens. 2020 Mar;46(2):e7-e10. doi: 10.1097/ICL.0000000000000602.
To report a patient with chronic ocular graft versus host disease who achieved long-term stability of a descemetocele using prosthetic replacement of the ocular surface ecosystem (PROSE) treatment.
Case report and literature review.
A 60-year-old white man, who underwent PROSE treatment 4 years earlier to address severe dry eyes secondary to ocular graft versus host disease, developed a central corneal ulcer that resulted in descemetocele formation. Because of the risks of surgical intervention in an immunocompromised patient with severe ocular surface disease, the descemetocele was monitored closely as the patient continued PROSE device wear. After 1 year with continued PROSE therapy, the patient's descemetocele remained stable without perforation and corrected visual acuity stabilized at 20/50 in the affected eye.
This is the first case that reports stabilization of a descemetocele with a PROSE device. For patients at high risk for postsurgical complications, PROSE treatment could be considered as an alternative to corneal transplantation and as an adjunct to other ocular therapies in patients with descemetocele formation.
报告 1 例慢性眼移植物抗宿主病患者，该患者使用眼表面生态系统重建术（PROSE）治疗，实现了单纯疱疹性角膜水肿的长期稳定。
病例报告和文献复习。
1 名 60 岁白人男性，4 年前因眼移植物抗宿主病继发严重干眼症行 PROSE 治疗，后出现中央角膜溃疡，导致单纯疱疹性角膜水肿。由于免疫功能低下且伴有严重眼表面疾病的患者手术干预风险较高，因此密切监测单纯疱疹性角膜水肿情况，同时继续佩戴 PROSE 装置。在继续 PROSE 治疗 1 年后，患者的单纯疱疹性角膜水肿保持稳定，未穿孔，患眼矫正视力稳定在 20/50。
这是首例使用 PROSE 装置稳定单纯疱疹性角膜水肿的病例报告。对于术后并发症风险较高的患者，PROSE 治疗可作为角膜移植的替代疗法，并可作为其他眼表治疗方法的辅助手段，用于单纯疱疹性角膜水肿患者。
