Dong Siyuan, Roberts Steven A, Chen Shuang, Zhong Xinwen, Yang Shize, Qu Xiaohan, Xu Shun
Department of Thoracic Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Shenyang, Liaoning, China.
Ott lab, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, USA.
BMC Surg. 2019 Apr 15;19(1):38. doi: 10.1186/s12893-019-0500-1.
We present a critical comparison of lobectomy and sub-lobar resection in elderly patients with early stage non-small cell lung cancer using meta-analytical techniques.
A literature search was conducted between the period of December 1997 to March 2019 to identify the comparative studies evaluating 1-, 3-, and 5-year survival rates. The pooled odds ratios (OR) and the 95% confidence intervals (95% CI) were calculated with either the fixed or random effect models, respectively.
Six retrospective studies are included in our meta-analysis for a total of 1205 patients. 843 of the individuals were treated with lobectomy, while 362 were treated with sub-lobar resection. We found no significant difference between the lobectomy and the sub-lobar resection in either of the 1-, 3-, or 5-year survival rates.
This study suggests that in elderly individuals with stage I NSCLC, a sub-lobar resection is statistically equivalent to the lobectomy in terms of 1-, 3-, and 5-year survival rates. Further large-scale randomized studies are needed to confirm our results.
我们运用荟萃分析技术，对老年早期非小细胞肺癌患者行肺叶切除术和肺段以下切除术进行了批判性比较。
在1997年12月至2019年3月期间进行文献检索，以确定评估1年、3年和5年生存率的比较研究。分别采用固定效应模型或随机效应模型计算合并比值比（OR）和95%置信区间（95%CI）。
我们的荟萃分析纳入了6项回顾性研究，共1205例患者。其中843例接受肺叶切除术，362例接受肺段以下切除术。我们发现肺叶切除术和肺段以下切除术在1年、3年或5年生存率方面均无显著差异。
本研究表明，对于I期非小细胞肺癌老年患者，肺段以下切除术在1年、3年和5年生存率方面与肺叶切除术在统计学上相当。需要进一步开展大规模随机研究来证实我们的结果。
