Park Nicollet/HealthPartners, Department of Sexual Medicine and Male Infertility, Minneapolis, Minnesota, USA.
Park Nicollet/HealthPartners, Department of Sexual Medicine and Male Infertility, Minneapolis, Minnesota, USA.
Sex Med Rev. 2020 Jan;8(1):92-99. doi: 10.1016/j.sxmr.2019.03.003. Epub 2019 Apr 12.
Premature ejaculation (PE) is among the most common sexual dysfunctions that affect men. Currently, topical medications are considered a first-line treatment option for PE, with no specific medication having market approval in the United States specifically for the treatment of PE. Topical agents for PE include eutectic mixture of local anesthetics cream, topical eutectic mixture for premature ejaculation spray, severance secret-cream, resiniferatoxin, and an assortment of over-the-counter treatments, including medicated condoms, sprays, and wipes.
Given the paucity of controlled studies for these treatment modalities, the goal of this article is to review the currently available options for PE to help educate providers in appropriate treatment options.
Comprehensive review of published literature, as well as clinical experience were evaluated to determine efficacy of known treatments for PE.
The topical treatment options and efficacy of these options for PE were reviewed. Eutectic mixture of local anesthetics, topical eutectic mixture for premature ejaculation, severance secret-cream, resiniferatoxin, and medicated condoms are the mainstay of treatment. Each has certain risks and benefits associated with use as described, as well as relative cost of use.
Although data supporting the effectiveness of topical agents for PE is limited, prior clinical trials demonstrate increases in timed intravaginal ejaculatory latency time and improved patient-partner sexual satisfaction survey scores on some treatment options.
More research is needed to evaluate efficacy, cost-effectiveness, potential side effects, and benefits of combined medical and psychological intervention for better ejaculatory control. Butcher MJ, Zubert T, Christiansen K, et al. Topical Agents for Premature Ejaculation: A Review. Sex Med Rev 2020;8:92-99.
早泄（PE）是最常见的男性性功能障碍之一。目前，局部用药被认为是治疗 PE 的一线选择，没有一种特定的药物在美国获得市场批准专门用于治疗 PE。PE 的局部治疗药物包括局部麻醉剂乳膏的共晶混合物、早泄共晶喷雾、断交秘膏、树脂毒素以及各种非处方治疗药物，包括有药物的避孕套、喷雾剂和湿巾。
鉴于这些治疗方式的对照研究较少，本文旨在回顾目前可用于治疗 PE 的各种选择，以帮助教育提供者了解合适的治疗选择。
综合评估已发表的文献和临床经验，以确定已知治疗 PE 的方法的疗效。
回顾了 PE 的局部治疗选择和这些选择的疗效。共晶混合局麻药、早泄共晶喷雾、断交秘膏、树脂毒素和有药物的避孕套是治疗的主要方法。每种方法都有其使用的风险和益处，以及相对的使用成本。
尽管支持 PE 局部治疗药物的有效性的数据有限，但先前的临床试验表明，一些治疗选择可增加定时阴道内射精潜伏期时间，并提高患者-伴侣的性满意度调查评分。
需要更多的研究来评估联合医疗和心理干预对改善射精控制的疗效、成本效益、潜在副作用和益处。Butcher MJ, Zubert T, Christiansen K, et al. Topical Agents for Premature Ejaculation: A Review. Sex Med Rev 2020;8:92-99.
