Wei Peng-Lu, Gu Hao, Guan Shuang, Su Yuan-Yuan, Liu Qiong, Liu Jun, Wang Zhong
Institution of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.
Zhongguo Zhong Yao Za Zhi. 2019 Mar;44(5):1041-1047. doi: 10.19540/j.cnki.cjcmm.2019.0020.
To analyze the medication features and regularity of prescriptions of traditional Chinese medicines in treating patients with coronary heart disease angina pectoris based on the launched Chinese patent medicines. In the article,we collected all of the launched Chinese patent medicines for treating coronary heart disease and angina pectoris from the Chinese patent medicine value assessment information database,and set up a medical record normalized database,then carried out the classification of syndromes. The medication features and prescription rules for angina pectoris were analyzed by frequency statistics and association rules(IBM SPSS Modeler 14. 1 Premiums software,Apriori algorithm). Finally,a total of 170 prescriptions were selected,and 197 Chinese herbs were included,involving to totally 11 syndrome types,in which blood stasis syndrome,Qi stagnation and blood stasis syndrome,Qi deficiency and blood stasis syndrome,Qi-Yin deficiency and blood stasis syndrome were the main syndrome types. The frequency of single-herb medicines for the four main syndrome types,the combination of commonly used medicines,and the core prescriptions were summarized. After comparing the core prescriptions of the four syndrome types,we could analyze the medication features and prescription rules. In conclusion,the therapeutic principle is blood-activating and stasis-dissolving,and consideration was also given to promoting Qi,invigorating Qi and resuscitation and invigorating Qi-Yin. The main medicines include Danshen(Salvia Miltiorrhizae Radix et Rhizoma) and Chuan-xiong(Chuanxiong Rhizoma). According to different types of syndromes,Chinese herbal medicines are added,such as Jiangxiang(Dalbergiae Odoriferae Lignum), Chishao(Paeoniaeradix Rubra), Sanqi(Notoginseng Radix et Rhizoma), Honghua(Carthami Flos),Bingpian(Borneolum Syntheticum),Renshen(Ginseng Radix et Rhizoma). Frequency statistics and association rules are combined to explore the medication features and core prescriptions,which provide ideas for the treatment of angina pectoris and the development of new drugs.
基于已上市的中成药分析治疗冠心病心绞痛患者的中药用药特点及方剂规律。在本文中，我们从中成药价值评估信息数据库中收集了所有已上市的治疗冠心病心绞痛的中成药，建立了病历规范化数据库，然后进行了证型分类。通过频率统计和关联规则（IBM SPSS Modeler 14.1 Premiums软件，Apriori算法）分析心绞痛的用药特点和方剂规律。最终，共筛选出170首方剂，纳入197味中药，涉及11种证型，其中血瘀证、气滞血瘀证、气虚血瘀证、气阴两虚血瘀证为主要证型。总结了四种主要证型的单味药用药频率、常用药组合及核心方剂。比较四种证型的核心方剂后，分析用药特点和方剂规律。综上所述，治疗原则为活血化瘀，兼顾行气、益气回阳及益气养阴。主要药物包括丹参和川芎。根据不同证型加用中药，如降香、赤芍、三七、红花、冰片、人参。结合频率统计和关联规则探索用药特点和核心方剂，为心绞痛的治疗及新药研发提供思路。
