Cui Yi-Ran, Liu Xin, Shen Dan, Yang Hong-Jun, Tang Shi-Huan
Institute of Chinese Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Department of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Zhongguo Zhong Yao Za Zhi. 2016 Feb;41(3):528-531. doi: 10.4268/cjcmm20160328.
In this study, formulas containing Salviae Miltiorrhizae Radix et Rhizoma-Carthami Flos in the database of Dictionary of Chinese Medicine Prescription (DCMP) were extracted by using traditional Chinese medicine inheritance support system (TCMISS). The drugs pairs and formula composition rules were analyzed with data mining methods, such as association rules, improved mutual information method and complex system entropy clustering. Totally 39 formulas were included in this study and involved 280 Chinese medicines. The top 5 Chinese medicines most frequently used were Danggui (Angelica sinensis), Chuanxiong (Ligusticum chuanxiong), Xiangfu (Cyperi Rhizoma), Baishao(Radix Paeoniae Alba), Taoren(Prunus persica) and Shengdihuang (Radix Rehmanniae Recens). Six core medicinal pairs were obtained through clustering analysis, namely Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Xiangfu (Cyperi Rhizoma)-Honghua (Carthami Flos), Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Baishao (Radix Paeoniae Alba)-Honghua (Carthami Flos), Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Danggui (A. sinensis)-Xiagnfu (Cyperi Rhizoma)-Honghua (Carthami Flos), Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Danggui (A. sinensis)-Baishao (Radix Paeoniae Alba)-Honghua (Carthami Flos), Honghua (Carthami Flos)-Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Baishao (Radix Paeoniae Alba)-Danggui (A. sinensis), Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Baishao (Radix Paeoniae Alba)-Honghua (Carthami Flos)-Danggui (A. sinensis). The support degree was set at 11 (38.46%), with a confidence coefficient of 80%, and then 38 associated pairs were screened. These results suggested that Salviae Miltiorrhizae Radix et Rhizoma, Carthami Flos is often combined with herbs for activating blood and promoting circulation of qi to treat gynecopathy, stasis blood pain syndrome, stroke and other syndromes.
本研究运用中医传承辅助系统（TCMISS），从《中医方剂大辞典》数据库中提取含丹参-红花的方剂。采用关联规则、改进的互信息法、复杂系统熵聚类等数据挖掘方法，分析药物对及方剂组成规律。本研究共纳入39首方剂，涉及280味中药。使用频率最高的前5味中药为当归、川芎、香附、白芍、桃仁、生地黄。通过聚类分析得到6个核心药对，即丹参-香附-红花、丹参-白芍-红花、丹参-当归-香附-红花、丹参-当归-白芍-红花、红花-丹参-白芍-当归、丹参-白芍-红花-当归。设定支持度为11（38.46%），置信度为80%，筛选出38个关联对。这些结果表明，丹参、红花常与活血化瘀、行气之药配伍，用于治疗妇科疾病、瘀血疼痛证、中风等病症。
