He Yu-Min, Ai Ke, He Chun-Xi, Zhang Chang-Cheng, Yuan Ding, Cai San-Jin
Medical College of China Three Gorges University Yichang 443002,China Third-grade Pharmacological Laboratory on TCM Approved by State Administration of Traditional Chinese Medicine,China Three Gorges University Yichang 443002,China.
Third-grade Pharmacological Laboratory on TCM Approved by State Administration of Traditional Chinese Medicine,China Three Gorges University Yichang 443002,China Ren-He Hospital of China Three Gorges University Yichang 443002,China.
Zhongguo Zhong Yao Za Zhi. 2019 Jan;44(2):249-260. doi: 10.19540/j.cnki.cjcmm.20181101.016.
Panax japonicus( PJ) is a valuable medicinal plant belonging to the genus Panax of Araliaceae,the recumbent rhizome of which is widely used in clinic therapy,healthcare products and as cosmetic additives with functions of dissipating stasis,reducing swelling,stanching bleeding,and reinforcing deficiency,etc. PJ contains abundant levels of oleanane-and dammarane-type triterpene saponins,which are considered as the material basis for exerting pharmacodynamic action. Based on the previous researches,more than110 triterpene saponins have been reported from PJ. These triterpene saponins were summarized in this review,and could be classified into dammarenediol Ⅱ,protopanaxadiol,protopanaxatiol,ocotillol,oleanolic acid,ursolic acid and miscellaneous subtypes,according to their molecular skeletons in biosynthesis processes. Further more,the structural features of these triterpene saponins in the seven different subtypes,together with their~(13)C-NMR spectroscopic characteristics were described,hoping to provide available information for chemical diversity research of PJ.
竹节参是五加科人参属的一种珍贵药用植物，其横卧根茎在临床治疗、保健品及化妆品添加剂中广泛应用，具有化瘀、消肿、止血、补虚等功效。竹节参含有丰富的齐墩果烷型和达玛烷型三萜皂苷，这些被认为是发挥药效作用的物质基础。基于以往研究，已从竹节参中报道了110多种三萜皂苷。本文对这些三萜皂苷进行了总结，根据其生物合成过程中的分子骨架，可分为达玛二醇Ⅱ、原人参二醇、原人参三醇、奥克梯隆型、齐墩果酸型、熊果酸型及其他亚型。此外，还描述了这七种不同亚型三萜皂苷的结构特征及其13C-NMR光谱特征，希望能为竹节参的化学多样性研究提供有用信息。
