Wu Qing-Hua, Li Bing-Tao, Tu Jun
Research Center for Differentiation and Development of Traditional Chinese Medicine Basic Theory,Jiangxi University of Traditional Chinese Medicine Nanchang 330004,China Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology Nanchang 330004,China.
Research Center for Differentiation and Development of Traditional Chinese Medicine Basic Theory,Jiangxi University of Traditional Chinese Medicine Nanchang 330004,China.
Zhongguo Zhong Yao Za Zhi. 2019 Mar;44(6):1104-1109. doi: 10.19540/j.cnki.cjcmm.20181212.001.
Diabetes is a chronic disorder of glucose metabolism characterized by elevated blood glucose levels. With the improvement in living standards and the changes in lifestyle,T2 DM incidence has a dramatic increase in the past decades,bringing a series of public health problems. In the research and development field of diabetic drugs,T1 DM drugs are mainly long-acting sustained-release insulin preparations,whereas T2 DM drugs mainly are based on single target. T2 DM drugs usually have a good anti-hyperglycemic effect,but with side effects for long-term administration. Therefore,the research and development of hypoglycemic drugs focus on formula drugs with multi-component,multi-target and multi-pathway effects. In the similar principle of action,traditional Chinese medicine formula has achieved a good efficacy in the treatment of diabetes,with mild anti-hyperglycemic effects and multiple-component synergistic effects in intervening the pathogenesis of diabetes,including additive effect,synergy effect and toxicity scattering effect. This article mainly reviews clinical trials and mechanisms of action of traditional Chinese medicine formula for the treatment of diabetes,so as to provide a reference to the rational and effective clinical application of traditional Chinese medicine formula in treating diabetes.
糖尿病是一种以血糖水平升高为特征的慢性葡萄糖代谢紊乱疾病。随着生活水平的提高和生活方式的改变，2型糖尿病（T2 DM）的发病率在过去几十年中急剧上升，带来了一系列公共卫生问题。在糖尿病药物研发领域，1型糖尿病（T1 DM）药物主要是长效缓释胰岛素制剂，而T2 DM药物主要基于单一靶点。T2 DM药物通常具有良好的降血糖作用，但长期服用有副作用。因此，降糖药物的研发集中在具有多成分、多靶点和多途径作用的复方药物上。基于类似的作用原理，中药复方在糖尿病治疗中取得了良好疗效，具有温和的降血糖作用以及在干预糖尿病发病机制方面的多成分协同作用，包括相加作用、协同作用和毒性分散作用。本文主要综述中药复方治疗糖尿病的临床试验及作用机制，为中药复方合理有效地临床应用于糖尿病治疗提供参考。
