Ragino Yu I, Shcherbakova L V, Denisova D V, Kuzminykh N A, Yachmeneva M P, Voevoda M I
Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM - Branch of IC G SB RAS); B. Bogatkov Str., 175/1, Novosibirsk, 630089, Russian Federation.
Kardiologiia. 2019 Apr 13;59(3S):30-35. doi: 10.18087/cardio.2600.
The aim of the study was to investigate the prevalence of angina pectoris (AP) according to the standardized epidemiological questionnaire of Rose in the population of 25-45 years of Novosibirsk and to identify its association with some lipid and non-lipid risk factors for coronary heart disease (CHD).
Cross-sectional survey of the population aged 25-45 in Novosibirsk was carried out. The study included 1439 people (656 men and 783 women). Within the framework of the complex survey program, the standardized epidemiological questionnaire of Rose (WHO, 1984) was used. Blood levels of total cholesterol (total C), triglycerides (TG), low and high density lipoprotein cholesterol (LDL-C, HDL-C) were determinate by biochemical methods.
For all lipid indicators, significant differences were found between men and women. The levels of total C, TG and LDL-C were significantly higher, and the level of HDL-C was lower in men, than in women. According to the Rose questionnaire, out of 1439 people included in the study, 12 patients (0.8%) had AP (75% women). In persons with AP, blood levels of TG were 1.8 times higher, and the levels of HDL-C in blood was 1.2 times lower compared to persons without AP. Univariate analysis of associations of AP with CHD risk factors showed that the chance of developing angina pectoris in the population of 25-45 years was significantly increased in individuals with high blood TG levels (OR 3,515, DI 1,106-11,168, p = 0.039) and low HDL-C (OR 1,203, DI 1,054-1,372, p = 0.006). A natural, although statistically not significant (OR 3,165, p=0,055, due to the small number of groups with AP) increasing in the chance of developing AP in hypertension was detected.
In the young population of 25-45 years in Novosibirsk, elevated blood levels of TG, reduced levels of HDL-C, and hypertension were associated with AP, according to Rosecardiological questionnaire, which underlines the importance of conducting screening surveys of the young population to improve effective prevention and treatment of diseases.
本研究旨在依据罗斯标准化流行病学调查问卷，调查新西伯利亚25至45岁人群中心绞痛（AP）的患病率，并确定其与冠心病（CHD）一些脂质和非脂质危险因素的关联。
对新西伯利亚25至45岁人群进行横断面调查。该研究纳入1439人（656名男性和783名女性）。在综合调查项目框架内，使用了罗斯标准化流行病学调查问卷（世界卫生组织，1984年）。通过生化方法测定总胆固醇（总C）、甘油三酯（TG）、低密度和高密度脂蛋白胆固醇（LDL-C、HDL-C）的血液水平。
在所有脂质指标方面，男性和女性之间存在显著差异。男性的总C、TG和LDL-C水平显著高于女性，而HDL-C水平低于女性。根据罗斯调查问卷，在纳入研究的1439人中，12例患者（0.8%）患有AP（75%为女性）。与无AP者相比，AP患者的TG血液水平高1.8倍，血液中HDL-C水平低1.2倍。对AP与CHD危险因素关联的单因素分析表明，25至45岁人群中，血液TG水平高的个体发生心绞痛的几率显著增加（OR 3.515，DI 1.106 - 11.168，p = 0.039），HDL-C水平低的个体发生心绞痛的几率也显著增加（OR 1.203，DI 1.054 - 1.372，p = 0.006）。在高血压患者中，虽然在统计学上不显著（由于患有AP的组数量较少，OR 3.165，p = 0.055），但发生AP的几率有自然增加。
根据罗斯心脏病学调查问卷，在新西伯利亚25至45岁的年轻人群中，血液TG水平升高、HDL-C水平降低和高血压与AP相关，这突出了对年轻人群进行筛查调查以改善疾病有效预防和治疗的重要性。
