叶酸受体介导染色液（FRD）染色在筛查高级别宫颈病变中的意义研究。

Study on the Significance of Folate Receptor-Mediated Staining Solution (FRD) Staining in Screening High Grade Cervical Lesions.

机构信息

Department of Gynecology and Obstetrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland).

出版信息

Med Sci Monit. 2019 Apr 16;25:2792-2801. doi: 10.12659/MSM.911402.

DOI:10.12659/MSM.911402

PMID:30990212

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6545068/

Abstract

BACKGROUND The aim of this study was to investigate the significance of folate receptor-mediated staining solution (FRD) in examination of cervical lesions during gynecological examination. MATERIAL AND METHODS A total of 404 patients participated in this study. FRD staining was applied to screen high grade cervical lesions. ThinPrep cytology test (TCT) and human papillomavirus (HPV) testing were also used for screening high grade cervical lesions. Coincidence rate and KAPPA value of different methods were compared by SPSS software. RESULTS As for CIN2+ and CIN3+, sensitivities for HPV testing were (96.92% and 97.78%) >TCT classification 1 (90.77% and 91.11%) >FRD staining (80.00% and 86.67%) >TCT classification 2 (70.77% and 77.78%), respectively. While specificities for HPV testing were (7.08% and 6.44%) <TCT classification 1 (39.53% and 37.88%) <FRD staining (51.92% and 50.97%) <TCT classification 2 (70.80% and 69.36%), respectively. Coincidence rate and KAPPA value of FRD staining, TCT classification 1, TCT classification 2, and HPV testing for detecting CIN2+ results were 56.44% and 16.52%, 47.77% and 13.54%, 70.79% and 27.76%, and 21.53% and 1.36%, respectively. Coincidence rate and KAPPA value of FRD staining, TCT classification 1, TCT classification 2, and HPV testing versus CIN3+ results were 54.95% and 14.19%, 43.81% and 9.27%, 70.30% and 23.91%, and 17.08% and 1.12%, respectively. CONCLUSIONS FRD staining was capable of detecting cervical lesions rapidly and is a cost-effective method for routine cervical lesions screening.

摘要

背景

本研究旨在探讨叶酸受体介导的染色溶液（FRD）在妇科检查中检查宫颈病变的意义。

材料和方法

共有 404 例患者参与了这项研究。FRD 染色用于筛查高级别宫颈病变。液基薄层细胞学检测（TCT）和人乳头瘤病毒（HPV）检测也用于筛查高级别宫颈病变。采用 SPSS 软件比较不同方法的符合率和 KAPPA 值。

结果

对于 CIN2+和 CIN3+，HPV 检测的敏感性分别为（96.92%和 97.78%）>TCT 分类 1（90.77%和 91.11%）>FRD 染色（80.00%和 86.67%）>TCT 分类 2（70.77%和 77.78%），而 HPV 检测的特异性分别为（7.08%和 6.44%）<TCT 分类 1（39.53%和 37.88%）<FRD 染色（51.92%和 50.97%）<TCT 分类 2（70.80%和 69.36%）。FRD 染色、TCT 分类 1、TCT 分类 2 和 HPV 检测用于检测 CIN2+结果的符合率和 KAPPA 值分别为 56.44%和 16.52%、47.77%和 13.54%、70.79%和 27.76%和 21.53%和 1.36%。FRD 染色、TCT 分类 1、TCT 分类 2 和 HPV 检测用于检测 CIN3+结果的符合率和 KAPPA 值分别为 54.95%和 14.19%、43.81%和 9.27%、70.30%和 23.91%和 17.08%和 1.12%。