Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.
Department of Obstetrics and Gynecology, Chinese PLA General Hospital, Beijing, China.
Int J Gynaecol Obstet. 2020 Sep;150(3):379-384. doi: 10.1002/ijgo.13245. Epub 2020 Jul 19.
To evaluate the efficacy of folate receptor-mediated tumor detection (FRD) for identifying high-grade intraepithelial squamous lesions (HSIL) in the triage of women who are positive for human papillomavirus (HPV), and those with cytology findings of atypical squamous cells of undetermined significance (ASCUS).
A secondary analysis of prospectively collected data from 1504 women who had abnormal results during primary cervical cancer screening at 13 hospitals in Beijing, China, between November 2014 and August 2015. The detection accuracy of FRD was evaluated among HPV-positive women and women with ASCUS referred for colposcopy examination.
Among 1338 women with HPV, the percentage coincidence with pathology findings was higher for FRD (66.7%) than for cytology of ASCUS or higher (51.5%). The rate of colposcopy referral for cytology and FRD as a triage tool was 969 (72.4%) and 736 (55.0%), respectively. Thus, 233 (17.4%) fewer women would be referred for colposcopy by FRD. Among 476 women with cytology of ASCUS, the percentage coincidence with pathology findings was higher for FRD (63.4%) than for HPV (35.9%).
FRD was found to be a promising triage tool for women who are HPV-positive and those with cytology findings of ASCUS.
评估叶酸受体介导的肿瘤检测（FRD）在识别 HPV 阳性和细胞学表现为非典型鳞状细胞不能明确意义（ASCUS）的女性中高级别上皮内鳞状病变（HSIL）中的应用效果。
对 2014 年 11 月至 2015 年 8 月期间，中国北京 13 家医院初次宫颈癌筛查中发现异常的 1504 名女性前瞻性收集数据进行二次分析。评估 FRD 在 HPV 阳性女性和 ASCUS 转诊行阴道镜检查的女性中的检测准确性。
在 1338 名 HPV 阳性女性中，FRD 的病理结果符合率（66.7%）高于细胞学 ASCUS 或更高（51.5%）。作为一种分诊工具，细胞学和 FRD 分别有 969（72.4%）和 736（55.0%）名女性转诊阴道镜检查。因此，FRD 可使 233 名（17.4%）女性减少阴道镜检查。在 476 名细胞学 ASCUS 的女性中，FRD 的病理结果符合率（63.4%）高于 HPV（35.9%）。
FRD 是 HPV 阳性和细胞学 ASCUS 的女性有前途的分诊工具。
