Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK.
The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Cancer Cell. 2019 Apr 15;35(4):542-544. doi: 10.1016/j.ccell.2019.03.009.
Using longitudinal molecular profiling, Körber et al. propose in this issue of Cancer Cell that IDH-wild-type glioblastomas initiate years pre-diagnosis with chromosome-level alterations that drive cell proliferation but require survival-promoting mutations, commonly in the TERT promoter, to form a detectable tumor. Multiple subclones drive disease progression, creating a therapeutic challenge.
利用纵向分子谱分析，Körber 等人在本期《癌细胞》中提出，IDH 野生型胶质母细胞瘤在诊断前数年就出现染色体水平改变，这些改变驱动细胞增殖，但需要生存促进突变，通常在 TERT 启动子中，才能形成可检测的肿瘤。多个亚克隆驱动疾病进展，这给治疗带来了挑战。
