Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany.
Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany.
Behav Brain Res. 2019 Sep 2;369:111911. doi: 10.1016/j.bbr.2019.111911. Epub 2019 Apr 13.
Impulsivity is an enduring personality trait that is highly relevant for the development of neuropsychiatric disorders. Although impulse control disorders (ICD) are well-characterized non-motor features in Parkinson's disease (PD), mainly related to medication, little is known about neural correlates reflecting trait aspects of impulsivity in PD patients. Here, we address the question whether motor, attentional and non-planning components, measured by the Barratt Impulsiveness Scale (BIS-11), are distinctly related to cortical thickness and cortical folding abnormalities in PD when compared to age-matched healthy controls (HC).
We investigated cortical thickness (CT) and complexity of cortical folding (CCF) in 22 PD patients with moderately advanced disease stages without ICD and 18 HC using high-resolution structural magnetic resonance imaging (MRI) data. Surface-based data analysis was driven by CAT12 toolbox.
PD patients showed widespread CT loss in frontal, cingulate, temporo-parietal and occipital regions (FDR corrected at p < 0.05 using threshold-free cluster enhancement). Significant differences in CCF between groups were not found. Using a multiple regression model, CT in inferior and superior frontal, anterior cingulate and precentral regions significantly predicted BIS attentional subscores (p = 0.041).
These data suggest a specific cortical trajectory associated with impulsivity in moderately advanced staged PD patients. The attentional dimension of trait impulsivity appears to be specifically related to CT, in contrast to alterations of early neurodevelopmental markers, i. e. CCF. Our results shed light on structural correlates of trait impulsivity in PD patients and establish a baseline for future research into neural risk factors potentially predisposing to ICD development.
冲动性是一种持久的人格特质，与神经精神疾病的发展高度相关。虽然冲动控制障碍（ICD）是帕金森病（PD）中一种特征明确的非运动性特征，主要与药物有关，但对于反映 PD 患者冲动特质方面的神经相关性知之甚少。在这里，我们研究了巴瑞特冲动量表（BIS-11）测量的运动、注意力和非计划成分是否与 PD 患者的皮质厚度和皮质折叠异常明显相关，与年龄匹配的健康对照组（HC）相比。
我们使用高分辨率结构磁共振成像（MRI）数据，对 22 名无 ICD 的中度晚期 PD 患者和 18 名 HC 进行皮质厚度（CT）和皮质折叠复杂性（CCF）的研究。基于 CAT12 工具箱进行了基于表面的数据分析。
PD 患者在前额、扣带回、颞顶和枕叶区域出现广泛的 CT 丢失（采用 FDR 校正，在 p<0.05 时使用阈值自由聚类增强）。组间 CCF 差异无统计学意义。使用多元回归模型，下额和上额、前扣带回和中央前回的 CT 显著预测了 BIS 注意力子评分（p=0.041）。
这些数据表明，在中度晚期 PD 患者中，存在与冲动性相关的特定皮质轨迹。特质冲动的注意力维度似乎与 CT 密切相关，而与早期神经发育标志物的改变（即 CCF）不同。我们的结果揭示了 PD 患者特质冲动的结构相关性，并为未来研究潜在导致 ICD 发展的神经风险因素奠定了基础。
