Addiction, Development, and Psychopathology (ADAPT) lab, Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands; Department of Psychiatry, Academic Medical Center, University of Amsterdam, the Netherlands; Faculty of Movement and Behavioral Science, Department of Clinical, Neuro-, and Developmental Psychology, Section of Clinical Psychology, VU University, Amsterdam, the Netherlands.
Addiction, Development, and Psychopathology (ADAPT) lab, Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands; Department of Psychiatry, Academic Medical Center, University of Amsterdam, the Netherlands.
Psychiatry Res Neuroimaging. 2019 May 30;287:56-59. doi: 10.1016/j.pscychresns.2019.03.011. Epub 2019 Apr 5.
The current study investigated the combined effects of N-acetylcysteine and working memory (WM) training on behavioral and neural mechanisms of cue reactivity and WM in cocaine users in a randomized, double-blind design. Twenty-four of 38 cocaine-using men completed a 25-day treatment with either 2400 mg/day NAC or placebo. Both groups performed WM-training. During pre- and post-test lab-visits, neural mechanisms of cue reactivity and WM, and cue-induced craving and WM performance were assessed. Additionally, exploratory whole brain analyses were performed. Overall, the hypotheses were not confirmed, possibly due to small sample size, low WM-training adherence and/or ongoing substance use.
本研究采用随机、双盲设计，旨在探究 N-乙酰半胱氨酸（NAC）与工作记忆（WM）训练联合应用对可卡因使用者线索反应性和 WM 的行为及神经机制的影响。38 名可卡因使用者中，24 名男性完成了为期 25 天的治疗，分别接受 2400mg/天 NAC 或安慰剂治疗。两组均进行 WM 训练。在测试前和测试后的实验室访视中，评估了线索反应性和 WM 的神经机制，以及线索诱导的渴求感和 WM 表现。此外，还进行了探索性全脑分析。总体而言，由于样本量小、WM 训练依从性低和/或持续的物质使用，假设未得到证实。
