Department of Toxicogenomics, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands, 6229, ER Maastricht, the Netherlands.
Department of Toxicogenomics, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands, 6229, ER Maastricht, the Netherlands.
Environ Pollut. 2019 Jul;250:107-117. doi: 10.1016/j.envpol.2019.04.005. Epub 2019 Apr 8.
Polychlorinated biphenyls (PCBs) are a class of widespread environmental pollutants, commonly found in human blood, that have been suggested to be linked to the occurrence of sporadic Parkinson's disease (PD). It has been reported that some non-coplanar PCBs accumulate in the brains of female PD patients. To improve our understanding of the association between PCB exposure and PD risk we have applied whole transcriptome gene expression analysis in blood cells from 594 PCB-exposed subjects (369 female, 225 male). Interestingly, we observe that in females, blood levels of non-coplanar PCBs appear to be associated with expression levels of PD-specific genes. However, no such association was detected in males. Among the 131 PD-specific genes affected, 39 have been shown to display similar changes in expression levels in the substantia nigra of deceased PD patients. Especially among the down-regulated genes, transcripts of genes involved in neurotransmitter vesicle-related functions were predominant.
多氯联苯（PCBs）是一类广泛存在的环境污染物，通常存在于人类血液中，有研究表明其与散发性帕金森病（PD）的发生有关。据报道，一些非共平面的多氯联苯会在女性 PD 患者的大脑中积累。为了更好地理解 PCB 暴露与 PD 风险之间的关联，我们对 594 名 PCB 暴露者（369 名女性，225 名男性）的血细胞进行了全转录组基因表达分析。有趣的是，我们观察到在女性中，非共平面 PCBs 的血液水平似乎与 PD 特异性基因的表达水平有关。然而，在男性中没有检测到这种关联。在受影响的 131 个 PD 特异性基因中，有 39 个基因在已故 PD 患者的黑质中显示出相似的表达水平变化。特别是在下调的基因中，与神经递质囊泡相关功能的基因的转录本占主导地位。
