Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China.
Cell Commun Signal. 2018 Sep 12;16(1):57. doi: 10.1186/s12964-018-0266-6.
FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the processes of cell proliferation, self-renewal, and tumorigenesis. In most human cancers, FOXM1 is overexpressed, and this indicates a poor prognosis for cancer patients. FOXM1 maintains cancer hallmarks by regulating the expression of target genes at the transcriptional level. Due to its potential role as molecular target in cancer therapy, FOXM1 was named the Molecule of the Year in 2010. However, the mechanism of FOXM1 dysregulation remains indistinct. A comprehensive understanding of FOXM1 regulation will provide novel insight for cancer and other diseases in which FOXM1 plays a major role. Here, we summarize the transcriptional regulation, post-transcriptional regulation and post-translational modifications of FOXM1, which will provide extremely important implications for novel strategies targeting FOXM1.
叉头框蛋白 M1（FOXM1）是一种关键的增殖相关转录因子，在细胞周期中广泛具有时空表达。它与细胞增殖、自我更新和肿瘤发生过程密切相关。在大多数人类癌症中，FOXM1 过表达，这表明癌症患者的预后不良。FOXM1 通过在转录水平上调节靶基因的表达来维持癌症特征。由于其在癌症治疗中的潜在分子靶标作用，FOXM1 在 2010 年被评为年度分子。然而，FOXM1 失调的机制仍不清楚。全面了解 FOXM1 的调控将为 FOXM1 发挥主要作用的癌症和其他疾病提供新的见解。在这里，我们总结了 FOXM1 的转录调控、转录后调控和翻译后修饰，这将为靶向 FOXM1 的新策略提供极其重要的意义。
