Kala Chayanika, Athar Mohd, Kala Sanjay, Khan Lubna, Jauhari Ramendra K, Satsangi Amitabh
Department of Pathology, LPS Institute of Cardiology, Kanpur, Uttar Pradesh, India.
Department of Surgery, GSVM Medical College, Kanpur, Uttar Pradesh, India.
J Cytol. 2019 Apr-Jun;36(2):84-88. doi: 10.4103/JOC.JOC_47_18.
Triple negative breast cancer (TNBC), despite being the uncommon subtype, contributes a major portion to mortality and associated with poor prognosis. The purpose of this study was to evaluate the cytological criteria for the diagnosis of TNBC through fine-needle aspiration cytology (FNAC).
Clinical, cytological, histological, and immunohistochemical (IHC) data of 256 patients were evaluated, and patient were classified as TNBC and non-TNBC phenotype by IHC. All cytological specimens were reviewed for 12 criteria: cellularity, tubule/gland formation, syncytial clusters, large bare nuclei, nuclear atypia, chromatin pattern, cell borders, nucleolus, cytoplasm, lymphocytic infiltrate, calcification, and necrosis. The Fischer's exact test was used to show test association.
Out of 256 patients, 82 patients were TNBC, and 174 patients were non-TNBC. TNBC phenotype showed statistically significant association to cellularity, tubule/gland formation, syncytial cluster formation, bare nuclei, nuclear atypia, cell borders, lymphocyte infiltration, and necrosis.
FNAC can be helpful in making diagnosis of TNBC and along with ER, PR, HER2 characterization, helpful in planning treatment strategy, saving time, manpower, and resources in the patient management.
三阴性乳腺癌（TNBC）虽是罕见亚型，但在乳腺癌死亡率中占很大比例且预后较差。本研究旨在通过细针穿刺细胞学检查（FNAC）评估TNBC诊断的细胞学标准。
评估了256例患者的临床、细胞学、组织学和免疫组化（IHC）数据，并通过IHC将患者分为TNBC和非TNBC表型。对所有细胞学标本按照12项标准进行复查：细胞密度、小管/腺泡形成、合体细胞团、大裸核、核异型性、染色质模式、细胞边界、核仁、细胞质、淋巴细胞浸润、钙化和坏死。采用Fisher精确检验显示检验关联性。
256例患者中，82例为TNBC，174例为非TNBC。TNBC表型在细胞密度、小管/腺泡形成、合体细胞团形成、裸核、核异型性、细胞边界、淋巴细胞浸润和坏死方面显示出统计学显著相关性。
FNAC有助于TNBC的诊断，并且结合雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体2（HER2）特征，有助于制定治疗策略，在患者管理中节省时间、人力和资源。
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